1. Interleukin 10: the critical role of a pleiotropic cytokine in food allergy
- Author
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Natalia Nedelkopoulou, Evangelia Farmaki, Ioannis Xinias, Dimos Gidaris, and Anil Dhawan
- Subjects
Pulmonary and Respiratory Medicine ,medicine.medical_treatment ,Immunology ,Population ,Single-nucleotide polymorphism ,Disease ,T-Lymphocytes, Regulatory ,03 medical and health sciences ,0302 clinical medicine ,Food allergy ,Animals ,Humans ,Immunology and Allergy ,Medicine ,Epigenetics ,education ,Genetic association ,education.field_of_study ,business.industry ,Dendritic Cells ,General Medicine ,Immunotherapy ,medicine.disease ,Interleukin-10 ,Interleukin 10 ,030228 respiratory system ,business ,Food Hypersensitivity ,030215 immunology - Abstract
Despite advances in research, the pathophysiology of food allergy has not yet been fully elucidated. IL-10 has both a pro- and anti-inflammatory effect on the development of food allergy and in order to understand its different immune-modulatory effects the factors that influence the inflammatory microenvironment need to be taken into account. Specific single nucleotide polymorphisms of the IL-10 gene seem to confer an increased risk of developing food allergy, but to date there is a substantial lack of genome- wide association studies regarding the genetic and epigenetic underpinnings of the disease. Special interest has been drawn to the development of allergen-specific regulatory CD4+CD25+ T-cells secreting IL-10 in the immunotherapy of allergic diseases. In addition, a distinct population of human tolerogenic dendritic cells (DC), DC-10 seems to hold great potential and could potentially serve as a therapeutic tool to improve the management of food allergy.
- Published
- 2020
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