1. Antibodies to Der p 1 and Der p 2 in allergic patients.
- Author
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Cruz RH, Ynoue LH, Aranda CS, Solé D, and Neto AC
- Subjects
- Adolescent, Adult, Animals, Case-Control Studies, Child, Child, Preschool, Cross-Sectional Studies, Enzyme-Linked Immunosorbent Assay, Female, Healthy Volunteers, Humans, Hypersensitivity, Immediate blood, Hypersensitivity, Immediate immunology, Immunoglobulin A blood, Immunoglobulin A immunology, Immunoglobulin E blood, Immunoglobulin E immunology, Immunoglobulin G blood, Immunoglobulin G immunology, Infant, Male, Young Adult, Antigens, Dermatophagoides immunology, Arthropod Proteins immunology, Cysteine Endopeptidases immunology, Dermatophagoides pteronyssinus immunology, Hypersensitivity, Immediate diagnosis
- Abstract
Introduction and Objectives: Atopic individuals are characterized by increased IgE production and Th2 response if exposed to certain antigens. It is known that the mother transfers anti-mite antibodies to the fetus and newborn, IgG thru the placenta, and IgA thru breastfeeding, but it is not clear whether there is a protective mechanism mediated by them concerning the development of future allergies. This study aimed to compare the levels of IgA, IgG, and IgE antibodies specific to Der p 1 and Der p 2 between atopic and healthy individuals., Methods: Serum samples of 98 patients and 44 healthy controls were subjected to quantification for specific IgE, IgG, and IgA antibodies against Der p 1 and Der p 2 by ImmunoCap
® and ELISA, and subjected to statistical analysis as indicated., Results: Atopic patients had higher serum levels of IgE, IgG, and IgA specific to Der p 1 and Der p 2. The correlation was more robust between IgE and IgG antibodies., Conclusions: Allergic patients produce higher levels of antibodies against Der p 1 and Der p 2 compared with healthy individuals. The mechanisms involved still require detailed studies.- Published
- 2021
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