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4. Avoidance measures for mite allergy—an update

Author

Klimek, Ludger, primary, Brehler, Randolf, additional, Bergmann, Karl-Christian, additional, Casper, Ingrid, additional, Klimek, Felix, additional, Hagemann, Jan, additional, Polk, Marie-Luise, additional, and Cuevas, Mandy, additional

Published
2023
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7. Practical handling of allergic reactions to COVID-19 vaccines

Author

Klimek, Ludger, Bergmann, Karl-Christian, Brehler, Randolf, Pfützner, Wolfgang, Zuberbier, Torsten, Hartmann, Karin, Jakob, Thilo, Novak, Natalija, Ring, Johannes, Merk, Hans, Hamelmann, Eckard, Ankermann, Tobias, Schmidt, Sebastian, Untersmayr, Eva, Hötzenecker, Wolfram, Jensen-Jarolim, Erika, Brockow, Knut, Mahler, Vera, and Worm, Margitta

Subjects
Corona virus, Vaccination, Allergic reaction, Position Article, Safety, Anaphylactic reaction
Abstract

Summary Background For the preventive treatment of the 2019 coronavirus disease (COVID-19) an unprecedented global research effort studied the safety and efficacy of new vaccine platforms that have not been previously used in humans. Less than one year after the discovery of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral sequence, these vaccines were approved for use in the European Union (EU) as well as in numerous other countries and mass vaccination efforts began. The so far in the EU approved mRNA vaccines BNT162b2 and mRNA-1273 are based on similar lipid-based nanoparticle carrier technologies; however, the lipid components differ. Severe allergic reactions and anaphylaxis after COVID-19 vaccination are very rare adverse events but have drawn attention due to potentially lethal outcomes and have triggered a high degree of uncertainty. Methods Current knowledge on anaphylactic reactions to vaccines and specifically the new mRNA COVID-19 vaccines was compiled using a literature search in Medline, PubMed, as well as the national and international study and guideline registries, the Cochrane Library, and the Internet, with special reference to official websites of the World Health Organization (WHO), US Centers for Disease Control and Prevention (CDC), Robert Koch Institute (RKI), and Paul Ehrlich Institute (PEI). Results Based on the international literature and previous experience, recommendations for prophylaxis, diagnosis and therapy of these allergic reactions are given by a panel of experts. Conclusion Allergy testing is not necessary for the vast majority of allergic patients prior to COVID-19 vaccination with currently licensed vaccines. In case of allergic/anaphylactic reactions after vaccination, allergy workup is recommended, as it is for a small potential risk population prior to the first vaccination. Evaluation and approval of diagnostic tests should be done for this purpose.

Published
2021

10. White paper on peanut allergy – part 1: Epidemiology, burden of disease, health economic aspects

Author

Lange, Lars, primary, Klimek, Ludger, additional, Beyer, Kirsten, additional, Blümchen, Katharina, additional, Novak, Natalija, additional, Hamelmann, Eckard, additional, Bauer, Andrea, additional, Merk, Hans, additional, Rabe, Uta, additional, Jung, Kirsten, additional, Schlenter, Wolfgang, additional, Ring, Johannes, additional, Chaker, Adam, additional, Wehrmann, Wolfgang, additional, Becker, Sven, additional, Mülleneisen, Norbert, additional, Nemat, Katja, additional, Czech, Wolfgang, additional, Wrede, Holger, additional, Brehler, Randolf, additional, Fuchs, Thomas, additional, Jakob, Thilo, additional, Ankermann, Tobias, additional, Schmidt, Sebastian M., additional, Gerstlauer, Michael, additional, Zuberbier, Torsten, additional, Spindler, Thomas, additional, and Vogelberg, Christian, additional

Published
2021
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11. Immunologically relevant aspects of the new COVID-19 vaccines—an ÖGAI (Austrian Society for Allergology and Immunology) and AeDA (German Society for Applied Allergology) position paper

Author

Untersmayr, Eva, primary, Förster-Waldl, Elisabeth, additional, Bonelli, Michael, additional, Boztug, Kaan, additional, Brunner, Patrick M., additional, Eiwegger, Thomas, additional, Eller, Kathrin, additional, Göschl, Lisa, additional, Grabmeier-Pfistershammer, Katharina, additional, Hötzenecker, Wolfram, additional, Jordakieva, Galateja, additional, Moschen, Alexander R., additional, Pfaller, Birgit, additional, Pickl, Winfried, additional, Reinisch, Walter, additional, Wiedermann, Ursula, additional, Klimek, Ludger, additional, Bergmann, Karl-Christian, additional, Brehler, Randolf, additional, Pfützner, Wolfgang, additional, Novak, Natalija, additional, Merk, Hans, additional, Rabe, Uta, additional, Schlenter, Wolfgang, additional, Ring, Johannes, additional, Wehrmann, Wolfgang, additional, Mülleneisen, Norbert, additional, Wrede, Holger, additional, Fuchs, Thomas, additional, and Jensen-Jarolim, Erika, additional

Published
2021
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12. Severe allergic reactions after COVID-19 vaccination with the Pfizer/BioNTech vaccine in Great Britain and USA

Author

Klimek, Ludger, primary, Novak, Natalija, additional, Hamelmann, Eckard, additional, Werfel, Thomas, additional, Wagenmann, Martin, additional, Taube, Christian, additional, Bauer, Andrea, additional, Merk, Hans, additional, Rabe, Uta, additional, Jung, Kirsten, additional, Schlenter, Wolfgang, additional, Ring, Johannes, additional, Chaker, Adam, additional, Wehrmann, Wolfgang, additional, Becker, Sven, additional, Mülleneisen, Norbert, additional, Nemat, Katja, additional, Czech, Wolfgang, additional, Wrede, Holger, additional, Brehler, Randolf, additional, Fuchs, Thomas, additional, Jakob, Thilo, additional, Ankermann, Tobias, additional, Schmidt, Sebastian M., additional, Gerstlauer, Michael, additional, Vogelberg, Christian, additional, Zuberbier, Thomas, additional, Hartmann, Karin, additional, and Worm, Margitta, additional

Published
2021
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13. Healthcare provision for insect venom allergy patients during the COVID-19 pandemic

Author

Worm, Margitta, primary, Ballmer-Weber, Barbara, additional, Brehler, Randolf, additional, Cuevas, Mandy, additional, Gschwend, Anna, additional, Hartmann, Karin, additional, Hawranek, Thomas, additional, Hötzenecker, Wolfram, additional, Homey, Bernhard, additional, Jakob, Thilo, additional, Novak, Natalija, additional, Pickert, Julia, additional, Saloga, Joachim, additional, Schäkel, Knut, additional, Trautmann, Axel, additional, Treudler, Regina, additional, Wedi, Bettina, additional, Sturm, Gunter, additional, and Rueff, Franziska, additional

Published
2020
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14. Correction to “ARIA guideline 2019: treatment of allergic rhinitis in the German health system”

Author

Klimek, Ludger, primary, Bachert, Claus, additional, Pfaar, Oliver, additional, Becker, Sven, additional, Bieber, Thomas, additional, Brehler, Randolf, additional, Buhl, Roland, additional, Casper, Ingrid, additional, Chaker, Adam, additional, Czech, Wolfgang, additional, Fischer, Jörg, additional, Fuchs, Thomas, additional, Gerstlauer, Michael, additional, Hörmann, Karl, additional, Jakob, Thilo, additional, Jung, Kirsten, additional, Kopp, Matthias V., additional, Mahler, Vera, additional, Merk, Hans, additional, Mülleneisen, Norbert, additional, Nemat, Katja, additional, Rabe, Uta, additional, Ring, Johannes, additional, Saloga, Joachim, additional, Schlenter, Wolfgang, additional, Schmidt-Weber, Carsten, additional, Seyfarth, Holger, additional, Sperl, Annette, additional, Spindler, Thomas, additional, Staubach, Petra, additional, Strieth, Sebastian, additional, Treudler, Regina, additional, Vogelberg, Christian, additional, Wallrafen, Andrea, additional, Wehrmann, Wolfgang, additional, Wrede, Holger, additional, Zuberbier, Torsten, additional, Bedbrook, Anna, additional, Canonica, Giorgio W., additional, Cardona, Victoria, additional, Casale, Thomas B., additional, Czarlewski, Wienczylawa, additional, Fokkens, Wytske J., additional, Hamelmann, Eckard, additional, Hellings, Peter W., additional, Jutel, Marek, additional, Larenas-Linnemann, Désirée, additional, Mullol, Joaquim, additional, Papadopoulos, Nikolaos G., additional, Toppila-Salmi, Sanna, additional, Werfel, Thomas, additional, and Bousquet, Jean, additional

Published
2020
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15. ARIA guideline 2019: treatment of allergic rhinitis in the German health system

Author

Klimek, Ludger, primary, Bachert, Claus, additional, Pfaar, Oliver, additional, Becker, Sven, additional, Bieber, Thomas, additional, Brehler, Randolf, additional, Buhl, Roland, additional, Casper, Ingrid, additional, Chaker, Adam, additional, Czech, Wolfgang, additional, Fischer, Jörg, additional, Fuchs, Thomas, additional, Gerstlauer, Michael, additional, Hörmann, Karl, additional, Jakob, Thilo, additional, Jung, Kirsten, additional, Kopp, Matthias V., additional, Mahler, Vera, additional, Merk, Hans, additional, Mülleneisen, Norbert, additional, Nemat, Katja, additional, Rabe, Uta, additional, Ring, Johannes, additional, Saloga, Joachim, additional, Schlenter, Wolfgang, additional, Schmidt-Weber, Carsten, additional, Seyfarth, Holger, additional, Sperl, Annette, additional, Spindler, Thomas, additional, Staubach, Petra, additional, Strieth, Sebastian, additional, Treudler, Regina, additional, Vogelberg, Christian, additional, Wallrafen, Andrea, additional, Wehrmann, Wolfgang, additional, Wrede, Holger, additional, Zuberbier, Torsten, additional, Bedbrook, Anna, additional, Canonica, Giorgio W., additional, Cardona, Victoria, additional, Casale, Thomas B., additional, Czarlewski, Wienczylawa, additional, Fokkens, Wytske J., additional, Hamelmann, Eckard, additional, Hellings, Peter W., additional, Jutel, Marek, additional, Larenas-Linnemann, Désirée, additional, Mullol, Joaquim, additional, Papadopoulos, Nikolaos G., additional, Toppila-Salmi, Sanna, additional, Werfel, Thomas, additional, and Bousquet, Jean, additional

Published
2019
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16. Guideline on diagnostic procedures for suspected hypersensitivity to beta-lactam antibiotics

Author

Wurpts, Gerda, primary, Aberer, Werner, additional, Dickel, Heinrich, additional, Brehler, Randolf, additional, Jakob, Thilo, additional, Kreft, Burkhard, additional, Mahler, Vera, additional, Merk, Hans F., additional, Mülleneisen, Norbert, additional, Ott, Hagen, additional, Pfützner, Wolfgang, additional, Röseler, Stefani, additional, Ruëff, Franziska, additional, Sitter, Helmut, additional, Sunderkötter, Cord, additional, Trautmann, Axel, additional, Treudler, Regina, additional, Wedi, Bettina, additional, Worm, Margitta, additional, and Brockow, Knut, additional

Published
2019
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19. Guideline for the diagnosis of drug hypersensitivity reactions

Author

Brockow, Knut, Przybilla, Bernhard, Aberer, Werner, Bircher, Andreas J., Brehler, Randolf, Dickel, Heinrich, Fuchs, Thomas, Jakob, Thilo, Lange, Lars, Pfützner, Wolfgang, Mockenhaupt, Maja, Ott, Hagen, Pfaar, Oliver, Ring, Johannes, Sachs, Bernhardt, Sitter, Helmut, Trautmann, Axel, Treudler, Regina, Wedi, Bettina, Worm, Margitta, Wurpts, Gerda, Zuberbier, Torsten, and Merk, Hans F.

Subjects
in vitro test, diagnosis, provocation test, skin test, Guideline, drug hypersensitivity
Abstract

Drug hypersensitivity reactions are unpredictable adverse drug reactions. They manifest either within 1-6 h following drug intake (immediate reactions) with mild to life-threatening symptoms of anaphylaxis, or several hours to days later (delayed reactions), primarily as exanthematous eruptions. It is not always possible to detect involvement of the immune system (allergy). Waiving diagnostic tests can result in severe reactions on renewed exposure on the one hand, and to unjustified treatment restrictions on the other. With this guideline, experts from various specialist societies and institutions have formulated recommendations and an algorithm for the diagnosis of allergies. The key principles of diagnosing allergic/hypersensitivity drug reactions are presented. Where possible, the objective is to perform allergy diagnostics within 4 weeks-6 months following the reaction. A clinical classification of symptoms based on the morphology and time course of the reaction is required in order to plan a diagnostic work-up. In the case of typical symptoms of a drug hypersensitivity reaction and unequivocal findings from validated skin and/or laboratory tests, a reaction can be attributed to a trigger with sufficient confidence. However, skin and laboratory tests are often negative or insufficiently reliable. In such cases, controlled provocation testing is required to clarify drug reactions. This method is reliable and safe when attention is paid to indications and contraindications and performed under appropriate medical supervision. The results of the overall assessment are discussed with the patient and documented in an "allergy passport" in order to ensure targeted avoidance in the future and allow the use of alternative drugs where possible.

Published
2015

21. Correction to: Guideline for the diagnosis of drug hypersensitivity reactions

Author

Brockow, Knut, primary, Przybilla, Bernhard, additional, Aberer, Werner, additional, Bircher, Andreas J., additional, Brehler, Randolf, additional, Dickel, Heinrich, additional, Fuchs, Thomas, additional, Jakob, Thilo, additional, Lange, Lars, additional, Pfützner, Wolfgang, additional, Mockenhaupt, Maja, additional, Ott, Hagen, additional, Pfaar, Oliver, additional, Ring, Johannes, additional, Sachs, Bernhardt, additional, Sitter, Helmut, additional, Trautmann, Axel, additional, Treudler, Regina, additional, Wedi, Bettina, additional, Worm, Margitta, additional, Wurpts, Gerda, additional, Zuberbier, Torsten, additional, and Merk, Hans F., additional

Published
2017
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