Search

Your search keyword '"Gornet, Jean-Marc"' showing total 11 results
Start Over Author "Gornet, Jean-Marc" Journal alimentary pharmacology & therapeutics
11 results on '"Gornet, Jean-Marc"'

1. Impact of vedolizumab therapy on extra‐intestinal manifestations in patients with inflammatory bowel disease: a multicentre cohort study nested in the OBSERV‐IBD cohort

Author

Tadbiri, S., Peyrin‐Biroulet, L., Serrero, M., Filippi, J., Pariente, B., Roblin, X., Buisson, A., Stefanescu, C., Trang‐Poisson, C., Altwegg, R., Marteau, P., Vaysse, T., Bourrier, A., Nancey, S., Laharie, D., Allez, M., Savoye, G., Gilletta, C., Gagniere, C., Vuitton, L., Viennot, S., Aubourg, A., Pelletier, A.‐L., Bouguen, G., Abitbol, V., Fumery, M., Claudepierre, P., Bouhnik, Y., Amiot, A., Amiot, Aurelien, Gagniere, Charlotte, Serrero, Melanie, Grimaud, Jean‐Charles, Peyrin‐Biroulet, Laurent, Zallot, Camille, Bigard, Marc‐Andre, Filippi, Jerome, Hebuterne, Xavier, Pariente, Benjamin, Nachury, Maria, Desreumaux, Pierre, Roblin, Xavier, Del Tedesco, Emilie, Buisson, Anthony, Bommelaer, Gilles, Stefanescu, Carmen, Bouhnik, Yoram, Boureille, Arnaud, Trang‐Poisson, Caroline, Altwegg, Romain, Marteau, Philippe, Dray, Xavier, Carbonnel, Franck, Vaysse, Thibaud, Seksik, Philippe, Beaugerie, Laurent, Cosnes, Jacques, Sokol, Harry, Landman, Cecilia, Bourrier, Anne, Nancey, Stephane, Boschetti, Gilles, Laharie, David, Poullenot, Florian, Allez, Matthieu, Gornet, Jean‐Marc, Baudry, Clautilde, Savoye, Guillaume, Moreau, Jacques, Vuitton, Lucine, Koch, Stephane, Viennot, Stephanie, Aubourg, Alexandre, Picon, Laurence, Pelletier, Anne‐Laure, Sickersen, Gaelle, Bouguen, Guillaume, Abitbol, Vered, Chaussade, Stanislas, Fumery, Mathurin, Nahon, Stephane, Winkfield, Betsy, Brixi‐benmansour, Hedia, Gincul, Rodica, Barberis, Jean‐Christophe, Bonaz, Bruno, Michiels, Christophe, Zerbib, Franck, Bourrier de Beauregard, Marie, Locher, Christophe, Davin‐Couve, Sophie, Poirette, Armelle, Guillem, Laurence, Stetiu‐Mocanu, Monica, Philippe, Beau, Beorchia, Sylvain, and Al Qaddi, Jawad

Published
2018
Full Text
View/download PDF

2. A clinical decision support tool may help to optimise vedolizumab therapy in Crohn’s disease

Author

Dulai, Parambir S., Amiot, Aurélien, Peyrin-Biroulet, Laurent, Jairaith, Vipul, Serrero, Mélanie, Filippi, Jérome, Singh, Siddharth, Pariente, Benjamin, Loftus, Edward V., Roblin, Xavier, Kane, Sunanda, Buisson, Anthony, Siegel, Corey A., Bouhnik, Yoram, Sandborn, William J., Lasch, Karen, Rosario, Maria, Feagan, Brian G., Bojic, Daniela, Trang-Poisson, Caroline, Shen, Bo, Altwegg, Romain, Sands, Bruce E., Colombel, Jean-Frederic, Carbonnel, Franck, Kochhar, Gursimran, Meserve, Joseph, Barsky, Maria, Boland, Brigid S., Gagniere, Charlotte, Bigard, Marc-André, Zallot, Camille, Grimaud, Jean-Charles, Hebuterne, Xavier, Nachury, Maria, Desreumaux, Pierre, del Tedesco, Emilie, Bommelaer, Gilles, Koliani-Pace, Jenna L., Stefanescu, Carmen, Boureille, Arnaud, Hirten, Robert, Ungaro, Ryan, Vaysse, Thibaud, Bohm, Matthew, Varma, Sashidhar, Fischer, Monika, Hudesman, David, Chang, Shannon, Bourrier, Anne, Seksik, Philippe, Beaugerie, Laurent, Cosnes, Jacques, Sokol, Harry, Landman, Cécilia, Lukin, Dana, Weiss, Aaron, Marteau, Philippe, Dray, Xavier, Nancey, Stephane, Boschetti, Gilles, Laharie, David, Poullenot, Florian, Allez, Matthieu, Gornet, Jean-Marc, Baudry, Clautilde, Savoye, Guillaume, Moreau, Jacques, Vuitton, Lucine, Koch, Stéphane, Viennot, Stéphanie, Aubourg, Alexandre, Picon, Laurence, Pelletier, Anne-Laure, Sickersen, Gaelle, Bouguen, Guillaume, Abitbol, Vered, Chaussade, Stanislas, Nahon, Stéphane, Fumery, Mathurin, Winkfield, Betsy, Brixi-Benmansour, Hedia, Gincul, Rodica, Barberis, Jean-Christophe, Bonaz, Bruno, Michiels, Christophe, Zerbib, Frank, Beauregard, Marie Bourrier, Locher, Christophe, Davin-Couve, Sophie, Poirette, Armelle, Guillem, Laurence, Stetiu-Mocanu, Monica, Philippe, Beau, Beorchia, Sylvain, Al Qaddi, Jawad, Swaminath, Arun, Observ-Ibd, Getaid, Collaboration, Victory Cohorts, Groupe d’Étude Thérapeutique des Affections Inflammatoires du Tube Digestif (GETAID), Service d'Hépato-gastro-entérologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Nutrition-Génétique et Exposition aux Risques Environnementaux (NGERE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), University of Western Ontario (UWO), Centre Hospitalier Universitaire de Nice (CHU Nice), University of California [San Diego] (UC San Diego), University of California (UC), Mayo Clinic [Rochester], Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte (M2iSH), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre de Recherche en Nutrition Humaine d'Auvergne (CRNH d'Auvergne)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Dartmouth Hitchcock Medical Center, Service de Gastroentérologie [Hôpital Beaujon], Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CICECO Department of chemistry and physics, Universidade de Aveiro, Robarts Research Institute [Canada], Centre hospitalier universitaire de Nantes (CHU Nantes), Institut des Maladies de l'Appareil Digestif, Université de Nantes (UN), Centre d’Investigation Clinique de Nantes (CIC Nantes), Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre hospitalier universitaire de Nantes (CHU Nantes), Columbia University Irving Medical Center (CUIMC), Icahn School of Medicine at Mount Sinai [New York] (MSSM), AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Early detection of Colon Cancer using Molecular Markers and Microbiota (EA 7375) (EC2M3), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Assistance Publique - Hôpitaux de Marseille (APHM), Université Côte d'Azur (UCA), Service des Maladies de l'Appareil Digestif et de la Nutrition [CHRU Lille], Hôpital Claude Huriez [Lille], CHU Lille-CHU Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service de Gastro-entérologie et Hépatologie [CHU Saint-Etienne], Service de neurologie [Le Kremlin Bicêtre], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bicêtre, Indiana University - Purdue University Indianapolis (IUPUI), Indiana University System, CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre de Recherche Saint-Antoine (CRSA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Equipes Traitement de l'Information et Systèmes (ETIS - UMR 8051), Ecole Nationale Supérieure de l'Electronique et de ses Applications (ENSEA)-Centre National de la Recherche Scientifique (CNRS)-CY Cergy Paris Université (CY), Sorbonne Université (SU), Autophagie infection et immunité - Autophagy Infection Immunity (APY), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), CHU Bordeaux [Bordeaux], Hôpital Haut-Lévêque [CHU Bordeaux], Hopital Saint-Louis [AP-HP] (AP-HP), Service d'Endocrinologie, Diabétologie, Maladies Métaboliques, Hôpital Avicenne, Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau (ADEN), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service d'Hépato-Gastroentérologie [CHU Rouen], Hôpital Charles Nicolle [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), UNIROUEN - UFR Santé (UNIROUEN UFR Santé), Normandie Université (NU)-Normandie Université (NU), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Service de Gastro-Entérologie [CHRU Besançon], Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Groupe innovation et ciblage cellulaire (GICC), EA 7501 [2018-...] (GICC EA 7501), Université de Tours (UT), Hépato-Gastro-Onco-Entérologie [CHRU de Tours], Centre de recherche sur l'Inflammation (CRI (UMR_S_1149 / ERL_8252 / U1149)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Service d'hépato-gastro-entérologie [Hôpital Saint-Louis, APHP], Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Hôpital Cochin [AP-HP], Université Sorbonne Paris Cité (USPC), Groupe Hospitalier Intercommunal Le Raincy-Montfermeil, Périnatalité et Risques Toxiques - UMR INERIS_I 1 (PERITOX), Institut National de l'Environnement Industriel et des Risques (INERIS)-Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, CHU Amiens-Picardie, Observatory on Efficacy and of Vedolizumab in Patients With Inflammatory Bowel Disease Study Group, Hôpital Edouard Herriot [CHU - HCL], Hospices Civils de Lyon (HCL), Centre Hospitalier Universitaire [Grenoble] (CHU), Service d'Hépato-Gastro-Entérologie (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Grand Hôpital de l'Est Francilien (GHEF), Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), Service de gastroentérologie [CHU Saint-Etienne], Service de Gastroentérologie et nutrition [CHU Saint-Antoine], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre International de Recherche en Infectiologie - UMR (CIRI), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hôpital Charles Nicolle [Rouen]-CHU Rouen, and CHU Toulouse [Toulouse]

Subjects
Adult, Male, medicine.medical_specialty, [SDV]Life Sciences [q-bio], Disease, Antibodies, Monoclonal, Humanized, Antiviral Agents, Clinical decision support system, Vedolizumab, Cohort Studies, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Crohn Disease, Gastrointestinal Agents, Internal medicine, medicine, Humans, Pharmacology (medical), 030212 general & internal medicine, Young adult, Optimising Vedolizumab in Crohn's Disease, Crohn's disease, Hepatology, business.industry, Patient Selection, Gastroenterology, Middle Aged, Decision Support Systems, Clinical, medicine.disease, Hepatitis C, Treatment Outcome, Calibration, Original Article, Female, 030211 gastroenterology & hepatology, Observational study, Onset of action, Drug Monitoring, business, Algorithms, medicine.drug, Cohort study
Abstract

International audience; Background A clinical decision support tool (CDST) has been validated for predicting treatment effectiveness of vedolizumab (VDZ) in Crohn's disease. Aim To assess the utility of this CDST for predicting exposure-efficacy and disease outcomes. Methods Using data from three independent datasets (GEMINI, GETAID and VICTORY), we assessed clinical remission rates and measured VDZ exposure, rapidity of onset of action, response to dose optimisation and progression to surgery by CDST-defined response groups (low, intermediate and high). Results A linear relationship existed between CDST-defined groups, measured VDZ exposure, rapidity of onset of action and efficacy in GEMINI through week 52 (P < 0.001 at all time points across three CDST-defined groups). In GETAID, CDST predicted differences in clinical remission at week 14 (AUC = 0.68) and rapidity of onset of action (P = 0.04) between probability groups. The high-probability patients did not benefit from shortening of infusion intervals, and differences in onset of action between the high-intermediate and low-probability groups within GETAID were no longer significant when including low-probability patients who received a week 10 infusion. CDST predicted a twofold increase in surgery risk over 12 months of VDZ therapy among low- to intermediate-probability vs high-probability patients (adjusted HR 2.06, 95% CI 1.33-3.21). Conclusions We further extended the clinical utility of a previously validated VDZ CDST, which accurately predicts at baseline exposure-efficacy relationships and rapidity of onset of action and could be used to help identify patients who would most benefit from interval shortening and those most likely to require surgery while on active therapy.

Published
2019

3. Excess risk of urinary tract cancers in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study

Author

Bourrier, A., Carrat, F., Colombel, J.-F., Bouvier, A.-M., Abitbol, V., Marteau, P., Cosnes, J., Simon, T., Peyrin-Biroulet, L., Beaugerie, L., Gendre, Jean-Pierre, Lémann, Marc, Hébuterne, Xavier, Cortot, Antoine, Bouhnik, Yoram, Laharie, David, Dupas, Jean Louis, Flourié, Bernard, Lerebours, Eric, Allez, Matthieu, Messing, Bernard, Cadiot, Guillaume, Soulé, Jean-Claude, Gornet, Jean-Marc, Veyrac, Michel, Duclos, Bernard, Beau, Philippe, Bourreille, Arnaud, Baumer, Philippe, Carbonnel, Franck, Heresbach, Denis, Metman, Etienne-Henry, Florent, Christian, Blain, Antoine, Faucheron, Jean-Luc, Bonaz, Bruno, Roblin, Xavier, Potier, Pascal, Boehm, Christian, Kurtz, Thierry, Lamouliatte, Hervé, Nion-Larmurier, Isabelle, Delchier, Jean-Charles, Chaussade, Stanislas, Weiss, Anne Marie, Cézard, Jean Pierre, Siproudhis, Laurent, Nahon, Stéphane, Sondag, Daniel, Jian, Raymond, Souquet, Jean-Christophe, Bord, Pierre, Coffin, Benoit, Dʼalmagne, Hélène, Delasalle, Patrick, Fournier, Régis, Cavicchi, Maryan, Souffran, Marc-Henry, Vandromme, Luc, Guedon, Claire, Seksik, Philippe, Michiels, Christophe, Renard, Pascal, Rogier, Patrice, Gouilloud, Sylvie, Rotenberg, André, Savoye, Guillaume, Thevenin, Alain, Mallet, Laurent, Brazier, Franck, Jean, Francois, Justum, Anne-Marie, Latrive, Jean-Paul, Gerbal, Jean-Luc, Pierrugues, Robert, Chardonnal, Gérard, Picon, Laurence, Reix, Nicole, Dʼaubigny, Nicolas Drouët, Uettwiller, Hervé, Mallet, Anne Courillon, Palacci, Alain, Bensaude, Raoul-Jacques, Bonniaud, Pierre, Empinet, Olivier, Nisard, Andrée, Rudelli, Alain, Tubiana, Bernard, Capelle, Philippe, Dabadie, Alain, Evard, Daniel, Julien, Pierre-Emile, Picon-Coste, Magali, Schneider, Stéphane, Goldfain, Denis, Bellanger, Jérôme, Blondelot, Jean-Pierre, Lamy, Philippe, Lemière, Sébastien, Mockly, Jean Francois, Pellat, Benoit, Gatineau-Sailliant, Gilles, Nalet, Bernard, Nancey, Stéphane, Kusielewicz, Daniel, Loison, Patrick, Popot, Jean-Michel, Merite, François, Roux, Jean-Pol, Afchain, Pauline, Blanquart, Alain, Heyries, Laurent, Reville, Marc, Viron, Dominique, Zerbib, Frank, Claviere, Christophe, Léostic, Didier, Pouderoux, Philippe, Moitry, Alain, Hagège, Hervé, Hugot, Jean-Pierre, Humeau, Benoit, Sabate, Jean-Marc, Lederman, Emmanuel, Lescut, Dominique, Luneau, Fabrice, Mesnard, Bruno, Smadja, Lionel, Steinberg, Michel, Brun, Marc, Macaigne, Gilles, Marchal, Jean Luc, Ollivier, Stéphane, Ouvry, Dominique, Perche, Jean Paul, Rambaud, Serge, Benamouzig, Robert, Cazenave, Jean Louis, Coffin, Jean-Charles, Blazquez, Martine, Lagneau, Marion, Person, Bruno, Wittersheim, Christian, Napoleon, Bertrand, Cemachovic, Israël, Iglicki, Franck, Howaizi, Mehran, Leprince, Eric, Leurent, Bruno, Morin, Thierry, Darsouni, Riad, Attar, Alain, Baron, Philippe, Breton, Anne, Gillion, Jean Marie, Guemene, Jean-Marc, Jouffre, Claude, Moreau, Xavier, Claude, Pierre, Quinton, André, Brichard, Jean Michel, Desaint, Benoit, Bouygues, Martin, Chatrenet, Philippe, Salmeron, Marcelo, Silvie, Jean, Waldner, Bruno, Emery, Yves, Moraillon, Armand, Kunkel, Daniel, Dubois, Philippe, Faure, Patrick, LʼHirondel, Christian, Labérenne, Jean-Eric, Moreau, Pierre, Pereira, Adelino, Plihon, Genevieve, Wolff, Thierry, Ngo, Yann, Boruchowicz, Arnaud, Jost, Béatrice, Gotlib, Jean Pierre, Danne, Odile, Raoux, Philippe, Ramond-Bouhali, Marie-José, Baetz, Andre, Veyres, Bruno, Chapoutot, Christian, Le Dréau, Gérard, Filippi, Jérôme, Mudry, Jean, Kalt, Philippe, Minault, Sophie, Bounin, Pierre-André, Andréani, Tony, Charneau, Jacky, Reijasse, Didier, Bolze, Jean-Louis, Thaunat, Jean Luc, Le Couteulx, Christian, Maurage, Chantal, Bader, Robert, Codjovi, Philippe, Migairou, Jean-Luc, Morali, Alain, Rey, Philippe, Molard, Bruno Richard, Petit, Richard, Koch, Stéphane, Cassan, Philippe, Deschamps, Jean-Paul, Caby, Christine Meicler, Meurisse, Jean-Jacques, Prades, Philippe, Boulant, James, Diacono, Michel, Monsch, Jean-Marie, Dupuy, J-François, Bellaiche, Guy, Guegan, Martine, Comte, Jean-Marc, Cayla, Jean-Michel, Le Tallec, Francois, Meurisse, Franck, Desurmont, Philippe, Roget, Laurent, Bouyssou, Philippe, Le Gall, Bruno, Bloch, Francis, Larvol, Loic, Jullien, Monique, Moreau, Jacques, Rebouissoux, Laurent, Decroix, Bruno, Dib, Nina, Dieterling, Paul, Lenormand, Frédéric, Lagier, Emmanuel, Fallourd, Philippe, Charpin, Serge, Bertrand, Hugues, Bommelaer, Gilles, Battistelli, Daniel, Delon, Bernard, Dentant, Lionel, Dorval, Etienne, Dumortier, Jérôme, Gaye-Bareyt, Eric, Gerosa, Yves, Guez, Chantal, Mornet, Martine, Benfredj, Paul, Piperaud, René, Stremsdoerfer, Noel, Verdier, Eric, Grinholtz, Alain, Barjonet, Georges, See, Antoine, Arotçarena, Ramuntxo, Baudet, Anne, Broyer, Joel, Charachon, Antoine, Blondon, Hugues, Mouton, Pascal, Claudez, Hubert, Labat-Labourdette, Jacques, Haëm, Jacques, Estable, Patrick, Levy, Patrick, Rosenbaum, Alain, Balavoine, Yvon, Blanchi, Alain, Coutarel, Pierre, Delaperriere, Nadege, Dervichian, Michel, Marois, Francis, Seroka, Jacques, Michaud, Laurent, Leroy, Olivier, Meyran, Emmanuel, Poilroux, Bernard, Tensaouti, Abdallah, Paupard, Thierry, Agard, Dominique, Beaulieu, Sandrine, Benfiguig, Kader, Capony, Patrice, Cottereau, Jean, Desreumaux, Pierre, Dramard, Jean-Michel, Duché, Mathieu, Mamou, Patrick, Etienney, Isabelle, DʼAbrigeon, Gilles, Godeberge, Béatrice, Tucat, Gilbert, Puech, Jean, Roger, Jean, Lapalus, Marie-George, Bauret, Paul, Houcke, Philippe, Pornin, Béatrice, Champigneulle, Bruno, Cuissard, Laurent, David, Xavier-Richard, Lombard, Frédéric, Granveau, Antoine, Hamon, Jean-François, Ink, Olivier, Blondel, Fabienne, Namias, Alain, Pillon, Didier, Reignier, Antoine, Tordjman, Gilles, Christidis, Christos, Zirabe, Simon, Audebert, Michel, Bion, Eric, Bourgeaux, Claude, Poupardin, Cécile, Deplaix, Philippe, Fratini, Gérard, Garnier, Thierry, Desseaux, Gerard, Magois, Hervé, Lochum, Sylvain, Vergier, Jean-Francois, Texereau, Patrick, Rat, Christel, Uzzan, Francoise, Vidal, Alain, Vinante, Nadia, Watrin, Bernard, Wurtz-Huckert, Cécile, Barre, Bruno, Ferbus, Dominique Chaslin, Contou, Jean-François, Coupier, Dominique, David, Benoit, Gargot, Dany, Huc, Denis, Barraya, Remy, Faroux, Roger, Fourgeaud, Jean-Luc, Grimprel, Hubert, Auroux, Jean, Rey, Jean-François, Arnoux, Jean Pierre, Lentini, Franck, Tardy, Ludovic, Mouterde, Olivier, Spyckerelle, Claire, Vacherot, Bruno, Weissman, Alain, Alpérine, Michel, Le Sidaner, Anne, Bonnet-Eymard, Pierre-Olivier, Colson, Jean Louis, Pellet, Daniel, Deltombe, Bernard, Edouard, André, Maechel, Henri, Jaillet, Jean-Claude, Genes, Julien, Leveque, Anne-Marie, Lucidarme, Damien, Maignan, Philippe, Gehrke, Nathalie Mallier, Sanchez, Jérôme, Tusseau, Frank, Casteur, Alban, Bottlaender, Jacques, Constantini, Denis, Coton, Thierry, Even, Philippe, Druart, Francois, Riot, François, Gauchet, Jean-Michel, Hecquet, Geneviève, Henry, Gerard, Hochain, Patrick, Arpurt, Jean Pierre, Medini, Abdelkrim, Dartois-Hoguin, Michele, Moindrot, Henri, Emery, Philippe, Periac, Pierre, Prunier, Annie, Renkes, Pascal, Tawil-Longreen, Christine, Vincent, Edmond, Vitte, René-Louis, Loeb, Christian, Carwana, Alain, Barbereau, Didier, Bohon, Philippe, Corrieri-Baizeau, Céline, Sahy, Daniel, Derreveaux, Philippe, David, Dominique, Desbazeille, François, Fontenelle, Patrick, Slama, Jean Luc, Le Mercier, Yvon, Certin, Michel, Reig, Jean Jacques, Rosa, Isabelle, Helbert, Thierry, Tounian, Patrick, Turner, Luc, Perot, Valéry, Aillet, Luc, Pauwels, Arnaud, Barré, Philippe, Nury, Bernard, Cazalbou, Claude, Devulder, Franck, Durget, Alain, Dubroca, Jeanne, Gaudy, Daniele, Greff, Michel, Jacques, Christian, Lafarge, Jocelyne, Kezachian, Gilles, Le Gall, Ronan, Pariente, Alex, Pinault, Tiphaine, Bismuth, Michaël, Boyer-Darrigrand, Nathalie, Bretagnolle, Philippe, Carpentier, Stephane, Cholet, Franck, Theodore, Christian, Combes, Rémi, Combet, Francois, Delanoe, Christophe, De Montigny, Stéphanie, Soudan, Denis, Fourdan, Olivier, Minier, Gilles, Languepin, Jeanne, Roche, Jean, Ginies, Jean-Louis, Nouel, Olivier, Petitgars, Philippe, Robin, Edith, Hamm, Romain, Roques, Jean François, Roussin-Bretagne, Sylvie, Sénéjoux, Agnès, Muron, Sophie, Bardoux, Nicolas, Berthelemy, Philippe, Madonia, Patrick, Carles, Bertrand, Reynier, Catherine, Cuillerier, Emmanuel, Dadamessi, Innocenti, Danis, Jacques, Debenes, Bernard, Dubuc-Rey, Nathalie, Lesur, Gilles, Jouet, Pauline, Lenaerts, Catherine, Garret, Marc, Mineur, Alexandra, Chabry, Bernard, Pigot, Francois, Rossi, Valérie, Tennenbaum, Ruth, Salloum, Julien, Slaoui, Maurice Hakim, Mathieu, Stéphane, Papapietro, Valérie, Viola, Sheila, Bezet, Alexis, Altman, Claude, Audan, Alain, Calabet, Jean, Masliah, Claude, Fayemendy, Laurent, Duruy, Marc, Gauffeny, Benoit, Helie, Ludovic, Imani, Kamran, Janin-Manificat, Raoul, Galmiche, Jean-Paul, Kerlirzin, Anne, Bedenne, Laurent, Locher, Christophe, Michaudel, Gilles, Missonnier, Gilles, Rinaldi-Dovio, Michel, Rouillon, Jean-Michel, Ecuer, Stéphane, Patenotte, Arnaud, Bronstein, Jean Ariel, Baty, Vincent, Bougnol, Michel, Bourbon, Pierre, Cerbelaud, Philippe, Chavaillon, Annick, Boiffin, Franck, Dubern, Béatrice, De Laguierce, Isabelle Duval, Greco, Fernand, Bouhot, Florence, Godeberge, Philippe, Grandmaison, Brigitte, Gros, Pascal, Targues, Guy, Corallo, Jacques, Boutin, Jean, Guillan, Jacques, Barbieux, Jean Pierre, Lariviere, Isabelle Loury, Le Genissel, Henri, Leroi, Henri, Bellaiche, Marc, Elie-Legrand, Marie-Claire, Dapoigny, Michel, Denoyel, Philippe, Pienkowski, Patrice, Pouche, Philippe, Saurfelt, Marc Michel, Thorel, Jean Marie, Piche, Thierry, Travers, Bruno, Tuvignon, Patrick, Zalcberg, Marc, Boulay, Guy, Zamora, Christophe, Samama, Joelle, Ricotie, Etienne, De Fleury, Patrice, Maille, Francois, Mougenel, Jean Louis, Gonot, Olivier, Menat, Jean Philippe, Kaassis, Mehdi, Lang, Francoise, Abramowitz, Laurent, Ganne, Nathalie, Pecriaux, Olivier, Seyrig, Jacques-Arnaud, Sobhani, Iradj, Parmentier, Thierry, Van Nieuwenhuyse, Antoine, Weber, Francois-Xavier, Glibert, André, Bineau, Catherine, Canet, Bernard, Collin, Catherine, Cordet, Frederic, Parlier, David David, Carre, Dominique, Peytier, Annie, Fein, Francine, Barouk, Jerome, Dewannieux, Jacques, Hartwig, Johannes, Jouve, Jean-Louis, Laplane, Bertrand, Lascar, Gilles, Legrand, Christophe, Le Marchand, Pierre, Liebaert, Marie Pierre, Terdiman-Pire, Michele, Abdelli, Naceur, Neveu, Dominique, De La Lande, Philippe, De Saint Louvent, Patrick, Pelatan, Cécile, Petit, Agnès, Richecoeur, Martial, Texier, Frederic, Cazals, Jean Brice, Tissot, Bertrand, Mourrut, Christian, Doubremelle, Marie, Foltz, Marc, Gautier-Jubé, Florence, Martin, Jacques, Khouri, Elie, Lons, Thierry, Carlier-Bandu, Martine, Monnin, Jean-Luc, Roche, Hervé, Willemin, Bernard, Houard, Xavier, Fatisse, Abdelaziz, le Algard, Michè, Arab, Kamel, Borel, Isabelle, Lagarrigue, Cécile, Chryssostalis, Ariane, Boutroux, Dominique, Dupuychaffray, Jean-Pierre, Khaddari, Saïd, Mion, François, Puy-Montbrun, Thierry, Girardet, Jean-Philippe, Gury, Bruno, Landau, Alain, Le Bihan, Monique, Nieuviarts, Sandrine, Ollivry, Jean, Le Bourgeois, Philippe, Piquet, Marie-Astrid, Escartin, Michel-Pierre, Systchenko, Remi, Venezia, Franck, Wantiez, Michel, Lesage, Xavier, Zrihen, Elie, Aygalenq, Philippe, Dieumegard, Barbara, Savarieau, Bernard, Bulois, Philippe, Cattan, Stéphane, Diez, Jean-Lucien, Fauchot, Olivier, Durous, Eric, Gazut, Valérie, Guilleminet, Christian, Bories, Jean-Marc, Le Floch, Isabelle Joly, Vove, Jean-Paul, Lelouch, Stéphane, Lévy, Philippe, Lhopital, François, Marcato, Norma, Mozer-Bernardeau, Marianne, Nousbaum, Jean-Baptiste, Cattan, Philippe, Plane, Alain, Raymond, Jean-Michel, Roseau, Gilles, Rozental, Gerald, Boustière, Christian, Bonny, Corinne, Cordier-Collet, Mariepierre, Courat, Laurent, Croguennec, Bernard, Delaunay-Tardy, Karine, Labarriere, Damien, Geagea, Edmond, Gottrand, Frédéric, Gelsi, Eve, Thiefin, Gerard, Wohlschies, Eric, Miguet, Mathieu, Ponsot, Philippe, Suzanne, Jean, Teste, Yves, Gossart, Anne-Claire Dupont, Baroni, Jean-Luc, Benchaa, Benabdallah, Blanc, Georges, Maroy, Bernard, Bonjean, Philippe, Brézault, Catherine, Bridoux-Henno, Laure, Chayette, Claude, Auby, Dominique, Fiorucci, Robert, Galindo, Georges, Hubert, Gilles, Bonneau, Gilles, Marinier, Evelyne, Pouteau, Michele, Alamdari, Afchine, Delbende, Bruno, Chamouard, Patrick, DʼAbravanel, Pascale, DallʼOsto, Hélène, Hervé, Sophie, Lefebvre, Jean, Levoir, Damien, Lillo, Philippe, Rouch, Michel, Mathonnet, Muriel, De Lustrac, Mercédes, Ramond, François-Jean, Roupret, Bernard, and Soupison, Alain

Published
2016
Full Text
View/download PDF

4. Effectiveness and safety of ustekinumab maintenance therapy in 103 patients with ulcerative colitis: a GETAID cohort study

Author

Fumery, Mathurin, primary, Filippi, Jérôme, additional, Abitbol, Vered, additional, Biron, Amélie, additional, Laharie, David, additional, Serrero, Melanie, additional, Altwegg, Romain, additional, Bouhnik, Yoram, additional, Peyrin‐Biroulet, Laurent, additional, Gilletta, Cyrielle, additional, Roblin, Xavier, additional, Pineton de Chambrun, Guillaume, additional, Vuitton, Lucine, additional, Bourrier, Anne, additional, Nancey, Stephane, additional, Gornet, Jean‐Marc, additional, Nahon, Stephane, additional, Bouguen, Guillaume, additional, Viennot, Stephanie, additional, Nachury, Maria, additional, and Amiot, Aurelien, additional

Published
2021
Full Text
View/download PDF

6. Impact of abdominal or pelvic radiotherapy on disease activity in inflammatory bowel disease: a multicentre cohort study from the GETAID.

Author

Broussard, Doriane, Rivière, Pauline, Bonnet, Joelle, Fotsing, Ginette, Amiot, Aurélien, Peyrin‐Biroulet, Laurent, Rajca, Sylvie, Buisson, Anthony, Gilleta, Cyrielle, Pelletier, Anne‐Laure, Serrero, Melanie, Bouguen, Guillaume, Altwegg, Romain, Hebuterne, Xavier, Nancey, Stephane, Fumery, Mathurin, Cadiot, Guillaume, Nahon, Stephane, Rahier, Jean‐Francois, and Gornet, Jean‐Marc

Subjects
INFLAMMATORY bowel diseases, RADIOTHERAPY, COHORT analysis, URINARY organs
Abstract

Summary: Background: Abdominal or pelvic radiotherapy in inflammatory bowel disease (IBD) patients raises concerns regarding the risk of worsening of underlying disease. Aim: To assess the impact of radiotherapy on IBD course. Methods: A retrospective multicentre study including IBD patients exposed to abdominal or pelvic irradiation was conducted, retrieving IBD activity by semester (6‐month periods) before (from S‐4 to S‐1) and after (from S + 1 to S + 6) radiotherapy and IBD flare during follow‐up. Results: Sixty‐one patients (32 women, mean age 59 years), with 467 patient semesters of follow‐up, treated for digestive (n = 31), urinary tract (n = 23) and gynaecological cancers (n = 7) were included. Rates of IBD activity per semester were, respectively, 21% (95% CI: 16‐27) from S‐4 to S‐1; 12% (7‐19) from S + 1 to S + 3 (P = 0.15 vs S‐4 to S‐1) and 16% (10‐25) from S + 4 to S + 6 (P = 0.45 vs S‐4 to S‐1). With a median follow‐up of 156 weeks (interquartile range: 82‐365), rates of survival without IBD flare at 1 and 3 years after radiotherapy were 82.5% (73.2‐93.0) and 70.6% (58.8‐84.7). Moderate‐to‐severe acute radiotherapy‐induced gut toxicity and the absence of concomitant chemotherapy were independently associated with an increased risk of flare. Conclusion: Most patients with non‐active IBD can be safely treated with abdominal or pelvic radiotherapy. Patients having acute gut toxicity and those without concomitant chemotherapy should be more closely monitored in the post‐radiotherapy period. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

7. Effectiveness and safety of ustekinumab induction therapy for 103 patients with ulcerative colitis: a GETAID multicentre real‐world cohort study.

Author

Amiot, Aurélien, Filippi, Jérôme, Abitbol, Vered, Cadiot, Guillaume, Laharie, David, Serrero, Melanie, Altwegg, Romain, Bouhnik, Yoram, Peyrin‐Biroulet, Laurent, Gilletta, Cyrielle, Roblin, Xavier, Pineton de Chambrun, Guillaume, Vuitton, Lucine, Bourrier, Anne, Nancey, Stephane, Gornet, Jean‐Marc, Nahon, Stephane, Bouguen, Guillaume, Viennot, Stephanie, and Pariente, Benjamin

Subjects
ULCERATIVE colitis, DISEASE remission, PATIENT safety, COHORT analysis, INFLAMMATORY bowel diseases, ADVERSE health care events
Abstract

Summary: Background: Phase III trials have demonstrated the efficacy and safety of ustekinumab in moderate‐to‐severe ulcerative colitis (UC), but few real‐world data are currently available. Aim: To assess short‐term effectiveness and safety of ustekinumab in patients with UC. Methods: From January to September 2019, all patients with UC treated with ustekinumab in 20 French GETAID centres were retrospectively included. The primary outcome was steroid‐free clinical remission (partial Mayo Clinic score ≤2) at weeks 12‐16 without a rectal bleeding subscore >1. Results: Among the 103 patients included, 70% had been previously exposed to ≥2 anti‐TNF agents and 85% to vedolizumab. At weeks 12‐16, steroid‐free clinical remission and clinical remission rates were 35.0% and 39.8% respectively; the absence of rectal bleeding with normal stool frequency was noted in 19.4% of patients. Two patients discontinued ustekinumab before the week 12‐16 visit and underwent surgery. In multivariable analysis, a partial Mayo Clinic score >6 at inclusion (18.6% vs 46.7%, P = 0.003) and a history of both exposure to anti‐TNF and vedolizumab therapies (27.3% vs 80.0%, P = 0.001) were negatively associated with steroid‐free clinical remission at weeks 12‐16. Adverse events occurred in 7.8% of patients and serious adverse events in 3.9% of patients. Conclusion: In a cohort of highly refractory patients with UC with multiple prior drug failures, ustekinumab provided steroid‐free clinical remission in one‐third of cases at weeks 12‐16. Clinical severity and previous use of anti‐TNF and vedolizumab therapies were associated with ustekinumab failure at weeks 12‐16. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

8. Anti-TNF therapy for genital fistulas in female patients with Crohn's disease: a nationwide study from the Groupe d'Etude Thérapeutique des Affections Inflammatoires du tube Digestif (GETAID)

Author

Le Baut, Guillaume, primary, Peyrin-Biroulet, Laurent, additional, Bouguen, Guillaume, additional, Gornet, Jean-Marc, additional, Stefanescu, Carmen, additional, Amiot, Aurélien, additional, Laharie, David, additional, Altwegg, Romain, additional, Fumery, Mathurin, additional, Trang, Caroline, additional, Vuitton, Lucine, additional, Simon, Marion, additional, Gilletta de Saint Joseph, Cyrielle, additional, Nahon, Stéphane, additional, Caillo, Ludovic, additional, Del Tedesco, Emilie, additional, Plastaras, Laurianne, additional, Aubourg, Alexandre, additional, Pineton de Chambrun, Guillaume, additional, Seksik, Philippe, additional, and Viennot, Stéphanie, additional

Published
2018
Full Text
View/download PDF

9. Three‐year effectiveness and safety of vedolizumab therapy for inflammatory bowel disease: a prospective multi‐centre cohort study.

Author

Grimaud, Jean‐Charles, Zallot, Camille, Bigard, Marc‐Andre, Hebuterne, Xavier, Nachury, Maria, Desreumaux, Pierre, Del Tedesco, Emilie, Bommelaer, Gilles, Boureille, Arnaud, Dray, Xavier, Carbonnel, Franck, Seksik, Philippe, Beaugerie, Laurent, Cosnes, Jacques, Sokol, Harry, Landman, Cecilia, Boschetti, Gilles, Poullenot, Florian, Gornet, Jean‐Marc, and Baudry, Clautilde

Subjects
VEDOLIZUMAB, INFLAMMATORY bowel disease treatment, TREATMENT effectiveness, MEDICATION safety, CROHN'S disease, ULCERATIVE colitis, COHORT analysis
Abstract

Summary: Background: Cohort studies have described the short‐term effectiveness and safety of vedolizumab in treating patients with Crohn's disease (CD) and ulcerative colitis (UC), but data beyond 1 year are lacking. Aim: To assess the effectiveness and safety of vedolizumab after 162 weeks in patients with UC and CD. Methods: Between June and December 2014, 294 patients including 173 patients with CD and 121 with UC were treated with vedolizumab induction therapy. Among them, 149 continued to be treated with vedolizumab beyond week 54 (78 patients with CD and 71 with UC). Disease activity was assessed using the Harvey‐Bradshaw Index for CD and the partial Mayo Clinic score for UC. The primary outcome was steroid‐free clinical remission at week 162, computed for the whole population included at week 0. Results: Steroid‐free clinical remission rates at week 162 were 19.9% and 36.1% in patients with CD and UC respectively. Vedolizumab dose optimisation to 300 mg every 4 weeks instead of 300 mg every 8 weeks was at investigator's discretion and occurred in 58.7% and 52.1% of patients with CD and UC respectively. The 1‐, 2‐ and 3‐year persistence rates of vedolizumab were 48.5%, 31.4% and 26.3% respectively, in patients with CD and 61.0%, 49.9% and 42.9% respectively, in patients with UC. No new safety signal was identified. Conclusion: Vedolizumab is able to maintain steroid‐free clinical remission in patients with UC and CD up to week 162. Loss of response resulting in discontinuation of vedolizumab occurred in 10% of patients per year. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

10. Male gender, active smoking and previous intestinal resection are risk factors for post‐operative endoscopic recurrence in Crohn's disease: results from a prospective cohort study.

Author

Auzolle, Claire, Nancey, Stephane, Tran‐Minh, My‐Linh, Buisson, Anthony, Pariente, Benjamin, Stefanescu, Carmen, Fumery, Mathurin, Marteau, Philippe, Treton, Xavier, Hammoudi, Nassim, Jouven, Xavier, Seksik, Philippe, Allez, Matthieu, Cattan, Pierre, Chirica, Mirea, Munoz‐Bongrand, Nicolas, Corte, Hélène, Gornet, Jean‐Marc, Baudry, Clotilde, and Lourenco, Nelson

Subjects
CROHN'S disease, SURGICAL complications, INFLAMMATORY bowel diseases, ULCERATIVE colitis, OPERATIVE surgery
Abstract

Summary: Background: After ileocaecal resection for Crohn's disease (CD), inflammatory lesions frequently recur on the anastomosis and/or on the neo‐terminal ileum. Aim: To identify predictors of early post‐operative endoscopic recurrence. Methods: From September 2010 to September 2017, the REMIND group conducted a prospective nationwide study in nine French academic centres. Data were collected at the time of surgery and endoscopy, performed 6‐12 months after surgery. Endoscopic recurrence was defined as a Rutgeerts score ≥i2. Baseline factors associated with endoscopic recurrence were searched by univariate and multivariate regression analysis. Results: Two hundred and eighty‐nine CD patients were included. Endoscopy within 1 year following surgery was performed in 225 (78%) patients (104M/121F). Mean age and disease duration were 35 (12.2) and 8.8 (8.9) years respectively. Seventy (32%) patients were active smokers at surgery. One hundred and forty‐two (63%) patients received at least one anti‐TNF therapy before surgery. After surgery, 40 (18%) patients received thiopurines and 66 (29%) received an anti‐TNF agent. Endoscopic recurrence occurred in 107 (47%) patients. In multivariate analysis, male gender (OR = 2.48 [IC 95% 1.40‐4.46]), active smoking at surgery (OR = 2.65 [IC 95% 1.44‐4.97]) and previous resection (OR = 3.03 [IC 95% 1.36‐7.12]) were associated with a higher risk of endoscopic recurrence. Inversely, post‐operative anti‐TNF treatment decreased the risk of endoscopic recurrence (OR = 0.50 [IC 95% 0.25‐0.96]). Conclusions: Male gender, active smoking at surgery and previous intestinal resection are associated with a higher risk of endoscopic post‐operative recurrence, while post‐operative anti‐TNF treatment is associated with a lower risk. Linked Content This article is linked to Yamamoto and Kotze, and Imperatore et al papers. To view these articles visit https://doi.org/10.1111/apt.14985 and https://doi.org/10.1111/apt.14989. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

11. Risk of serious infection in healthcare workers with inflammatory bowel disease: a case‐control study of the Groupe d'Etude Thérapeutique des Affections Inflammatoires du tube Digestif (GETAID).

Author

the GETAID INFOPRO study group, Gagnière, Charlotte, Amiot, Aurelien, Viennot, Stephanie, Vuitton, Lucine, Stefanescu, Carmen, Bouguen, Guillaume, Bourrier, Anne, Seksik, Philippe, Gornet, Jean‐Marc, Abitbol, Vered, Marteau, Philippe, Cosnes, Jacques, DeWit, Olivier, Nancey, Stephane, Altwegg, Romain, Laharie, David, Reenaers, Catherine, Buisson, Anthony, and Pariente, Benjamin

Subjects
INFLAMMATORY bowel diseases, HEALTH care industry, HOSPITAL care, ADRENOCORTICAL hormones, TUBERCULOSIS, DISEASE risk factors
Abstract

Summary: Background: Whether healthcare workers with inflammatory bowel disease (IBD) are at increased risk of severe infection due to daily pathogen exposure is controversial. Aim: To assess the risk of severe infection in healthcare workers with IBD in a large multicentre case‐control study. Methods: The study population comprised 482 healthcare workers with IBD from 17 centres who were matched for gender, age, disease subtype and year of diagnosis to 482 controls (non‐healthcare workers with IBD). The study period was between the date of diagnosis of IBD and June 2016. Severe infection was defined as any community‐acquired infection that required hospitalisation. Results: With a median follow‐up of 9.3 years, 139 severe infections were recorded among cases and controls, including 30 Clostridium difficile infections, 33 severe viral infections, nine tuberculosis infections, 21 community‐acquired pneumonia and 46 others. No difference was observed between healthcare workers and controls regarding the overall incidence rates of severe infection. An increased risk of tuberculosis was noted in healthcare workers. In multivariate analysis in the entire study population, severe infection was associated with current exposure to corticosteroids (OR = 3.05, 95% CI [2.06‐4.52], P < 0.001), immunosuppressants (OR = 1.98, 95% CI [1.38‐2.84], P < 0.001) and anti‐TNF agents (OR = 2.93, 95% CI [2.02‐4.27], P < 0.001) and reduced with Crohn's disease (OR = 0.63, 95% CI [0.43‐0.91], P = 0.01). Conclusions: Healthcare workers with IBD do not have an increased risk of severe infection compared with other patients with IBD, except for tuberculosis. Screening for tuberculosis exposure should be assessed in this high‐risk population when treated with anti‐TNF agents. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results