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LINKED CONTENT: This article is linked to Ikegami et al papers. To view these articles, visit https://doi.org/10.1111/apt.17387 and https://doi.org/10.1111/apt.17420 [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Rønnow Sand et al papers. To view these articles, visit https://doi.org/10.1111/apt.17119 and https://doi.org/10.1111/apt.17234 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Verstockt et al papers. To view these articles, visit https://doi.org/10.1111/apt.16955 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Song et al papers. To view these articles, visit https://doi.org/10.1111/apt.17963 and https://doi.org/10.1111/apt.17983 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Song et al papers. To view these articles, visit https://doi.org/10.1111/apt.17963 and https://doi.org/10.1111/apt.17999 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to García et al papers. To view these articles, visit https://doi.org/10.1111/apt.17938 and https://doi.org/10.1111/apt.17973 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to García et al papers. To view these articles, visit https://doi.org/10.1111/apt.17938 and https://doi.org/10.1111/apt.17993 [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Cushing et al and Cushing and Ananthakrishnan papers. To view these articles, visit https://doi.org/10.1111/apt.15568 and https://doi.org/10.1111/apt.15621. [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Ikegami et al papers. To view these articles, visit https://doi.org/10.1111/apt.17387 and https://doi.org/10.1111/apt.17443 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Chen et al papers. To view these articles, visit https://doi.org/10.1111/apt.17392 and https://doi.org/10.1111/apt.17471 [ABSTRACT FROM AUTHOR]

Summary: Background: 5‐aminosalicylates (5‐ASA) are widely used in inflammatory bowel disease (IBD), but emerging evidence suggests that they may be safely withdrawn in significant subsets of patients. This is important to address: 5‐ASA therapy accounts for up to 25% of total healthcare costs in ulcerative colitis (UC), while almost a third of patients with Crohn's disease (CD) receive long‐term 5‐ASA despite no clear evidence of benefit. Further, rationalising medication burden may improve overall adherence and outcome. Aims: To summarise the rationale for 5‐ASA withdrawal, review the current evidence in both UC and CD and consider the data surrounding colorectal cancer (CRC) prevention, guiding an evidence‐based withdrawal strategy. Methods: PubMed was searched to identify relevant studies. Only papers published in English were reviewed, with priority given to randomised clinical trials and meta‐analyses. Results: For patients with UC, consideration of 5‐ASA withdrawal should be made on a case‐by‐case basis, but it appears safest for those in deep remission without any of the following risk factors: younger age (<40 years), remission for less than 2 years, a history of multiple flares, extensive disease. 5‐ASA withdrawal should also be considered in patients with UC escalated to biologic therapy who have achieved remission and in all patients with CD. Although 5‐ASA therapy may have chemopreventive benefits for CRC, the cost‐benefit ratio appears significant, and this indication is not justified by evidence in those who have achieved remission and are continuing therapy with other agents, or in those in sustained remission without a history of extensive disease. Conclusions: Although the majority of patients with IBD receive 5‐ASA during their disease course, safe withdrawal appears possible in many, with important implications for both health economics and patient experience. A number of unanswered questions, however, remain. [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Danese et al papers. To view these articles, visit https://doi.org/10.1111/apt.16753 and https://doi.org/10.1111/apt.16761 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Danese et al papers. To view these articles, visit https://doi.org/10.1111/apt.16753 and https://doi.org/10.1111/apt.16795 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Hanzel et al papers. To view these articles, visit https://doi.org/10.1111/apt.16609 and https://doi.org/10.1111/apt.16724 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Feagan et al papers. To view these articles, visit https://doi.org/10.1111/apt.16626 [ABSTRACT FROM AUTHOR]

Summary: Background: Clinical and endoscopic remission are treatment targets in ulcerative colitis (UC). The value of histologic healing in altering clinical outcomes among patients with complete endoscopic healing is not well established. Aim: To quantify the association between histologic activity and clinical relapse among patients with UC who were in complete endoscopic remission. Methods: This study included patients with UC from a prospective registry who were in complete endoscopic remission. Histologic activity was quantified by a senior gastrointestinal pathologist. Histologic activity was defined as lack of normalisation (Geboes score > 0) as well as histologically active disease (Geboes score ≥2.1 and ≥3.1). The primary outcome was clinical relapse within 2 years. Multivariable regression adjusting for potential confounders examined the independent predictive value of histologic changes. Results: The study included 83 patients (51% women) (median age 44 years; median disease duration 11 years). Forty‐one (49%) had complete histologic normalisation. Within two years, 26 (31%) experienced clinical relapse. Patients with complete histologic normalisation were less likely to experience relapse (5/41, 12%) compared to those without normalisation (21/42, 50%, P < 0.001) (multivariable OR 7.22, 95% confidence interval (CI) 2.48‐24.70) by the Geboes score. The individual components of the Geboes score predictive of relapse were architectural changes (P = 0.03) and increased chronic inflammatory infiltrate (P < 0.001). Conclusions: Complete histologic healing using the Geboes score was associated with reduced rates of clinical relapse among patients with UC in endoscopic remission. LINKED CONTENT This article is linked to Pai et al and Cushing et al and Ananthakrishnan papers. To view these articles, visit https://doi.org/10.1111/apt.15617 and https://doi.org/10.1111/apt.15621. [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Korzenik paper. To view this article, visit https://doi.org/10.1111/apt.15370. [ABSTRACT FROM AUTHOR]

Linked Content This article is linked to Wiskin and Sandhu, and Coughlan et al papers. To view these articles visit https://doi.org/10.1111/apt.14147 and https://doi.org/10.1111/apt.14070. [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Panaccione et al papers. To view these articles, visit https://doi.org/10.1111/apt.17816 and https://doi.org/10.1111/apt.17829 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Bokemeyer et al papers. To view these articles, visit https://doi.org/10.1111/apt.17616 and https://doi.org/10.1111/apt.17770 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Bokemeyer et al papers. To view these articles, visit https://doi.org/10.1111/apt.17616 and https://doi.org/10.1111/apt.17796 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Buisson et al papers. To view these articles, visit https://doi.org/10.1111/apt.17305 and https://doi.org/10.1111/apt.17351 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Buisson et al papers. To view these articles, visit https://doi.org/10.1111/apt.17305 and https://doi.org/10.1111/apt.17405 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Cortesi et al papers. To view these articles, visit https://doi.org/10.1111/apt.17261 and https://doi.org/10.1111/apt.17298 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Cortesi et al papers. To view these articles, visit https://doi.org/10.1111/apt.17261 and https://doi.org/10.1111/apt.17375 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Reijntjes et al papers. To view these articles, visit https://doi.org/10.1111/apt.17267 and https://doi.org/10.1111/apt.17302 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Reijntjes et al papers. To view these articles, visit https://doi.org/10.1111/apt.17267 and https://doi.org/10.1111/apt.17331 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Straatmijer et al papers. To view these articles, visit https://doi.org/10.1111/apt.17248 [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Khalili et al paper. To view this article, visit https://doi.org/10.1111/apt.15889 [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Taxonera et al papers. To view these articles, visit https://doi.org/10.1111/apt.16964 and https://doi.org/10.1111/apt.17054 [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Taxonera et al papers. To view these articles, visit https://doi.org/10.1111/apt.16964 and https://doi.org/10.1111/apt.17118 [ABSTRACT FROM AUTHOR]

In the paper, "Integrated safety analysis of filgotinib for ulcerative colitis: Results from SELECTION and SELECTIONLTE.",[1] published in Volume 58, issue 9 (1 November 2023), the authors have detected an error in the last sentence of paragraph 3.1 within their Results section (page 876) whereby the first two numbers should be transposed.The sentence should read as follows:Treatment exposure for FIL200, FIL100 and placebo in cohort 3 was 585.9, 387.8 and 2352.5 patient‐years, respectively.The authors apologise for this error. [Extracted from the article]

Linked Content This article is linked to Hammer et al, and Wang and Lin papers. To view these articles visit https://doi.org/10.1111/apt.13975 and https://doi.org/10.1111/apt.14085. [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Okabayashi et al papers. To view these articles, visit https://doi.org/10.1111/apt.16865 and https://doi.org/10.1111/apt.16925 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Okabayashi et al papers. To view these articles, visit https://doi.org/10.1111/apt.16865 and https://doi.org/10.1111/apt.16905 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Sagami et al papers. To view these articles, visit https://doi.org/10.1111/apt.16817 and https://doi.org/10.1111/apt.16868 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Sagami et al papers. To view these articles, visit https://doi.org/10.1111/apt.16817 and https://doi.org/10.1111/apt.16895 [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Dong et al papers. To view these articles, visit https://doi.org/10.1111/apt.15592 and https://doi.org/10.1111/apt.15776. [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Ollech et al paper. To view this article, visit https://doi.org/10.1111/apt.15616. [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Shawihdi et al and Moore papers. To view these articles, visit https://doi.org/10.1111/apt.15315 and https://doi.org/10.1111/apt.15412. [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Dignass et al papers. To view these articles, visit https://doi.org/10.1111/apt.17622 and https://doi.org/10.1111/apt.17640 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Dignass et al papers. To view these articles, visit https://doi.org/10.1111/apt.17622 and https://doi.org/10.1111/apt.17656 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Bokemeyer et al paper. To view this article, visit https://doi.org/10.1111/apt.17616 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to D'Haens et al paper. To view this article, visit https://doi.org/10.1111/apt.17557 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Atia et al paper. To view this article, visit https://doi.org/10.1111/apt.17544 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Vasant et al paper. To view this article, visit https://doi.org/10.1111/apt.17502 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Sandborn et al papers. To view these articles, visit https://doi.org/10.1111/apt.16712 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Rubin et al papers. To view these articles, visit https://doi.org/10.1111/apt.16619 [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Worley et al and Worley & Faiz papers. To view these articles, visit https://doi.org/10.1111/apt.16202 and https://doi.org/10.1111/apt.16256 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Kochhar et al papers. To view these articles, visit https://doi.org/10.1111/apt.17570 and https://doi.org/10.1111/apt.17697 [ABSTRACT FROM AUTHOR]