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Dr Nick Kennedy stepped down from his position as Associate Editor with responsibility for IBD-related papers and was replaced by Dr Sree Subramanian. Randomised clinical trial: semaglutide versus placebo reduced liver steatosis but not liver stiffness in subjects with non-alcoholic fatty liver disease assessed by magnetic resonance imaging. Welcome to the first edition of I AP&T i for 2023. [Extracted from the article]

LINKED CONTENT: This article is linked to Myojin.et al's paper. To view this article, visit https://doi.org/10.1111/apt.16691 and https://doi.org/10.1111/apt.16862. [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Dhanda et al papers. To view these articles, visit https://doi.org/10.1111/apt.17307 and https://doi.org/10.1111/apt.17335 [ABSTRACT FROM AUTHOR]

Summary: Background: Although enteropathy due to angiotensin II receptor blockers (ARBs) has been known for over 10 years, clinicians' awareness of this condition is still low. Aims: To systematically review the literature about clinical phenotypes, distribution of mucosal changes throughout the gastrointestinal tract and prognosis of enteropathy due to ARBs. Methods: According to PRISMA guidelines, we searched PubMed and Embase for relevant articles up to November 6, 2023. We included full‐text papers, letters, case reports and case series describing enteropathy due to ARBs. Patients were classified into subgroups based on endoscopic and histological findings of different regions of the gastrointestinal tract. The protocol was registered with Open Science Framework (https://doi.org/10.17605/OSF.IO/TK67C). Results: We included 94 articles reporting 183 cases (101 female, mean age at diagnosis 69 ± 10 years). The clinical picture at diagnosis was characterised by severe diarrhoea (97%) and weight loss (84%, median −13 kg), leading to hospital admission in 167 (95%) patients. Olmesartan (90%) was most frequently implicated. Villous atrophy (VA) was reported in 164/183 (89%) patients. One hundred and nine had only VA, 12 had pan‐gastrointestinal involvement, 23 had VA and gastric involvement and 19 had VA and colon involvement (predominantly microscopic colitis). Outcomes were reported for 178/183 (97%) patients, who all recovered clinically on ARBs withdrawal. Histological recovery occurred in all 96 patients with VA at baseline who underwent follow‐up duodenal biopsy. Conclusions: Enteropathy due to ARBs is characterised by severe malabsorption often requiring hospital admission and can involve the entire gastrointestinal tract. Clinician awareness can lead to prompt diagnosis and excellent prognosis. [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Becchetti et al papers. To view these articles, visit https://doi.org/10.1111/apt.17192 and https://doi.org/10.1111/apt.17228 [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Faye et al papers. To view these articles, visit https://doi.org/10.1111/apt.17162 and https://doi.org/10.1111/apt.17200 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Verma et al papers. To view these articles, visit https://doi.org/10.1111/apt.17891 and https://doi.org/10.1111/apt.17913 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Hagström et al papers. To view these articles, visit https://doi.org/10.1111/apt.17374 and https://doi.org/10.1111/apt.17400 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Tong et al papers. To view these articles, visit https://doi.org/10.1111/apt.17263 and https://doi.org/10.1111/apt.17423 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Canivet et al papers. To view these articles, visit https://doi.org/10.1111/apt.16262 [ABSTRACT FROM AUTHOR]

The Alimentary Pharmacology & Therapeutics journal welcomes readers to its first edition of 2024. The journal received 1266 submissions between January and September 2023, accepting 130 of them, resulting in an acceptance rate of 10.3%. The journal aims to maintain a balance between hepatology and 'luminal' gastroenterology papers and offers authors the option to transfer their papers to affiliated journals if not accepted. The journal also discusses a change in the nomenclature for steatotic liver disease and highlights its 2-year impact factor and most highly cited and downloaded papers. The editors express their gratitude to the contributors and invite suggestions for improvement. [Extracted from the article]

LINKED CONTENT: This article is linked to Rivera–Andrade et al papers. To view these articles, visit https://doi.org/10.1111/apt.16948 and https://doi.org/10.1111/apt.17060 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Rivera‐Andrade et al papers. To view these articles, visit https://doi.org/10.1111/apt.16948 and https://doi.org/10.1111/apt.17061 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Dahl et al papers. To view these articles, visit https://doi.org/10.1111/apt.17201 and https://doi.org/10.1111/apt.17431 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Tong et al papers. To view these articles, visithttps://doi.org/10.1111/apt.17263 and https://doi.org/10.1111/apt.17409 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Park et al papers. To view these articles, visit https://doi.org/10.1111/apt.17257 and https://doi.org/10.1111/apt.17390 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Hocking et al paper. To view this article, visit https://doi.org/10.1111/apt.17309 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Paul et al paper. To view this article, visit https://doi.org/10.1111/apt.16133 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Alabsawy et al papers. To view these articles, visit https://doi.org/10.1111/apt.16790 and https://doi.org/10.1111/apt.16855 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Alabsawy et al papers. To view these articles, visit https://doi.org/10.1111/apt.16790 and https://doi.org/10.1111/apt.16809 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to LeGac et al papers. To view these articles, visit https://doi.org/10.1111/apt.16775 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Vittal et al papers. To view these articles, visit https://doi.org/10.1111/apt.16659 and https://doi.org/10.1111/apt.16784 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Dunne et al paper. To view this article, visit https://doi.org/10.1111/apt.17252 [ABSTRACT FROM AUTHOR]

Summary: Background: The nucleos(t)ide analogues (NAs) entecavir (ETV), tenofovir disoproxil fumarate (TDF) and tenofovir alafenamide (TAF) are preferred treatment options for patients with chronic hepatitis B infection (CHB). However, resistance to ETV has been reported, especially with prior exposure to other NAs, and long‐term TDF treatment has been associated with decline in renal function and loss of bone mineral density in some patients. Consequently, TAF may be preferable to ETV, TDF or other NAs in specific circumstances such as in patients with risk of bone or renal complications, elderly patients or those with previous NA experience. Aim: To provide a summary of the available efficacy and safety data following switch to TAF from other NAs in patients with CHB in clinical studies and real‐world settings. Methods: Literature searches were performed on PubMed and abstracts from three major international liver congresses between 2019 and 2021. Studies that included efficacy and/or safety data for patients with CHB switching from any NA to TAF were selected. Results: Thirty‐six papers and abstracts were included in this narrative review. Switching from TDF to TAF maintained or improved virological and biochemical responses with improved bone and renal safety. Switching from ETV or other NAs to TAF maintained or improved virological and biochemical responses and varying results for bone and renal safety. Conclusions: Switching to TAF appears to maintain or improve virological, biochemical and bone‐ and renal‐related safety outcomes. These data support the concept of switching to TAF in some patients with CHB based on their individual circumstances. [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Zheng et al papers. To view these articles, visit https://doi.org/10.1111/apt.16595 and https://doi.org/10.1111/apt.16715 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Dhanda et al papers. To view these articles, visit https://doi.org/10.1111/apt.17307 and https://doi.org/10.1111/apt.17366 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Jachs et al papers. To view these articles, visit https://doi.org/10.1111/apt.16945 and https://doi.org/10.1111/apt.17291 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Quigley et al papers. To view these articles, visit https://doi.org/10.1111/apt.17310 and https://doi.org/10.1111/apt.17354 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Attia et al paper. To view this article, visit https://doi.org/10.1111/apt.17233 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Wong et al papers. To view these articles, visit https://doi.org/10.1111/apt.17195 and https://doi.org/10.1111/apt.17244 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Becchetti et al papers. To view these articles, visit https://doi.org/10.1111/apt.17192 and https://doi.org/10.1111/apt.17258 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Algera et al papers. To view these articles, visit https://doi.org/10.1111/apt.17239 and https://doi.org/10.1111/apt.17279 [ABSTRACT FROM AUTHOR]

Summary: The disorders of gut–brain interactions (DGBI) are a spectrum of gastrointestinal (GI) disorders that involve the entire GI tract and are usually categorised into four major anatomic GI regions, oesophageal, gastroduodenal, bowel and anorectal. Irritable bowel syndrome (IBS), a bowel DGBI, is one of the most researched DGBI and has been the subject of copious epidemiological studies. Prevalence rates are based on diagnostic criteria. In the case of IBS, there are three central obstacles to attaining a clear picture of prevalence: the absence of biomarkers, the multitude of diagnostic criteria used over the years, and the heterogeneous nature of the methodology used in epidemiologic surveys. When the results of multiple studies, conducted over a long period of time, using different diagnostic criteria and different research methodology, and involving different study populations are pooled to determine a single summary prevalence rate it is difficult to interpret the results and to determine their reliability and significance. This pitfall is insufficiently recognised and unfortunate because prevalence rates are important for understanding the burden of disease, for allocating healthcare and research resources, and for incentivising and prioritising new treatments. The aims of the present paper are to highlight our knowledge and understanding of IBS epidemiology within the context of other DGBI, and to present strategies to improve epidemiological research, especially in advance of the new Rome V criteria, to be published in 2026. [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Nocerino et al and Philips & Abraham papers. To view these articles, visit https://doi.org/10.1111/apt.16404 and https://doi.org/10.1111/apt.16474 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Crawley et al papers. To view these articles, visit https://doi.org/10.1111/apt.16914 and https://doi.org/10.1111/apt.16951 [ABSTRACT FROM AUTHOR]

Summary: Background: Conflicting results exist on the association between Helicobacter pylori infection and gastro‐oesophageal reflux (GOR), and its complications, such as erosive oesophagitis (EO) and Barrett's oesophagus (BO). Aims: To explore the association of H. pylori infection with GOR symptoms and their complications Methods: We searched Embase, PubMed, Web of Science and Scopus databases through December 2020 for relevant articles. Regarding the association between H. pylori and GOR symptoms (heartburn, regurgitation or reflux), we included observational studies comparing the prevalence of GOR symptoms between H. pylori‐positive and ‐negative individuals. Concerning the association between H. pylori and complications of GOR, we included studies comparing the prevalence of EO or BO between H. pylori‐positive and ‐negative individuals. Results: In total, 36 papers were eligible. Based on seven cross‐sectional surveys, H. pylori infection was associated with a lower odds of GOR symptoms (odds ratio [OR] 0.74, 95% confidence interval [CI] 0.61‐0.90). However, in four case‐control studies, H. pylori infection was not associated with odds of GOR symptoms (OR 1.10, 95% CI 0.85‐0.1.43). In 26 cross‐sectional studies in patients with GOR symptoms, the OR for EO was 0.70 (95% CI 0.58‐0.84) in H. pylori‐positive vs ‐negative cases. Based on nine cross‐sectional studies in subjects with GOR complications, no significant association was found between H. pylori infection and either endoscopically‐diagnosed (OR 1.84, 95% CI 0.67‐5.02) or histologically confirmed (OR 0.85, 95% CI 0.60‐1.20) BO. Conclusions: Helicobacter pylori infection appears to be associated with a decreased odds of GOR symptoms and EO. In contrast, H. pylori infection did not seem to affect the odds of BO in patients with GER complications. [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Rønnow Sand et al papers. To view these articles, visit https://doi.org/10.1111/apt.17119 and https://doi.org/10.1111/apt.17234 [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Rønnow Sand et al papers. To view these articles, visit https://doi.org/10.1111/apt.17119 and https://doi.org/10.1111/apt.17249 [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Becchetti et al. papers. To view these articles, visit https://doi.org/10.1111/apt.17192 and https://doi.org/10.1111/apt.17245 [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Castro Tejera et al papers. To view these articles, visit https://doi.org/10.1111/apt.17182 [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Maccioni et al papers. To view these articles, visit https://doi.org/10.1111/apt.17177 [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Jalal et al papers. To view these articles, visit https://doi.org/10.1111/apt.17191 [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Pauwels et al papers. To view these articles, visit https://doi.org/10.1111/apt.17068 and https://doi.org/10.1111/apt.17183 [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Lin et al papers. To view these articles, visit https://doi.org/10.1111/apt.17089 [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Chaudhary et al and Chaudhary & Stanley papers. To view these articles, visit https://doi.org/10.1111/apt.16170 and https://doi.org/10.1111/apt.16368 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Hagström et al papers. To view these articles, visit https://doi.org/10.1111/apt.17374 and https://doi.org/10.1111/apt.17394 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Ogawa et al papers. To view these articles, visit https://doi.org/10.1111/apt.17107 and https://doi.org/10.1111/apt.17693. [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Taxonera et al paper. To view this article, visit https://doi.org/10.1111/apt.15804 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Deputy et al papers. To view these articles, visit https://doi.org/10.1111/apt.16800 and https://doi.org/10.1111/apt.16841 [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Black et al and Simmons & Taft papers. To view these articles, visit https://doi.org/10.1111/apt.16322 and https://doi.org/10.1111/apt.16345 [ABSTRACT FROM AUTHOR]