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Your search keyword '"Dinah S. Singer"' showing total 3 results
Start Over Author "Dinah S. Singer" Journal alcoholism, clinical and experimental research
3 results on '"Dinah S. Singer"'

1. Ethanol induces marked changes in lymphocyte populations and natural killer cell activity in mice

Author

John Wunderlich, Atsushi Kosugi, Michele Wallendal, Gary G. Meadows, and Dinah S. Singer

Subjects
Cytotoxicity, Immunologic, medicine.medical_specialty, Liquid diet, Alcohol Drinking, Ratón, T cell, Lymphocyte, Medicine (miscellaneous), Spleen, Mice, Inbred Strains, Thymus Gland, Biology, Toxicology, Natural killer cell, Major Histocompatibility Complex, Leukocyte Count, Mice, Internal medicine, medicine, Animals, Cytotoxicity, Ethanol, Lymphocyte Subsets, Killer Cells, Natural, Psychiatry and Mental health, Alcoholism, medicine.anatomical_structure, Endocrinology, Liver, CD8
Abstract

Treatment of mice in vivo with 5% w/v ethanol given in a liquid diet causes marked changes in spleen, peripheral blood, and thymus lymphocytes. In both the thymus and spleen, there is an acute cellular depletion resulting in a significant decrease in gross tissue size and cell number. In spleen and peripheral blood, the percentage of T lymphocytes is increased relative to B lymphocytes, but the ratio of CD4+/CD8+ T cell sub-populations remains unchanged. Splenic natural killer (NK) cell activity is increased in ethanol-consuming mice, although the percentage of NK1.1+ cells is relatively unchanged.

Published
1992

2. Evidence of increased class I MHC expression on human peripheral blood lymphocytes during acute ethanol intoxication

Author

Dinah S. Singer, Ron M. Walls, Michael A. Kolber, and Marion L. Hinners

Subjects
Adult, Male, Cellular immunity, Lymphocyte, Population, Medicine (miscellaneous), Toxicology, Major histocompatibility complex, Antigen, Immunity, medicine, Humans, Lymphocytes, education, Aged, education.field_of_study, biology, Ethanol, Histocompatibility Antigens Class I, Middle Aged, Histocompatibility, Psychiatry and Mental health, medicine.anatomical_structure, Gene Expression Regulation, Immunology, Humoral immunity, biology.protein, Alcoholic Intoxication
Abstract

Certain ethanol-related diseases in humans have been linked to disorders of immunity. Although humoral and cellular immunity have been studied, the precise mechanisms whereby ethanol use leads to tissue damage remain unknown. In order to explore the hypothesis that ethanol may lead to alteration in expression of tissue Class I major histocompatibility antigen causing an autoimmune phenomenon, a population of acutely ethanol-intoxicated patients was studied. Measurement of Class I major histocompatibility antigen on peripheral blood lymphocytes in this population showed a highly significant (p less than 0.01) increase over controls. The role that this increased antigenicity may play in the evolution of clinical disease is discussed.

Published
1988

3. Ethanol: an enhancer of transplantation antigen expression

Author

Leslie J. Parent, Dinah S. Singer, and Michael A. Kolber

Subjects
Adult, Male, Cell, Population, Medicine (miscellaneous), chemical and pharmacologic phenomena, Toxicology, Major histocompatibility complex, Cell Line, Major Histocompatibility Complex, Mice, Immune system, Antigen, MHC class I, medicine, Animals, Humans, Lymphocytes, education, Aged, Regulation of gene expression, Ovarian Neoplasms, education.field_of_study, Mice, Inbred C3H, biology, Dose-Response Relationship, Drug, Ethanol, Histocompatibility Antigens Class I, Histocompatibility Antigens Class II, Teratoma, Middle Aged, Transplantation, Psychiatry and Mental health, medicine.anatomical_structure, Gene Expression Regulation, Immunology, biology.protein, RNA, Female, Alcoholic Intoxication
Abstract

Major histocompatibility antigens (MHC) play a pivotal role in the immune response. Abnormal expression of MHC antigens has been correlated with aberrant regulation of the immune response. Studies on the effect of ethanol on class I MHC antigens demonstrate that ethanol significantly enhances their cell surface expression in a variety of cell lines in vitro. These changes in cell surface levels reflect increased intracellular protein synthesis and increased steady state mRNA levels. The effective ethanol concentrations (0.1-1.0%) are physiologically attainable. Measurement of class I MHC antigens on peripheral blood lymphocytes in a population of acutely ethanol-intoxicated patients showed a highly significant increase relative to controls. The possibility that the elevated levels of MHC antigens induced by ethanol may play a role in the evolution of ethanol-related disease is discussed.

Published
1989

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