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Background: Thalassemia is a group of heterogeneous disorders with variable severity characterized by defect in globin chain synthesis due to genetic defect. Hypercoagulable state in thalassemia is well known complication affecting 1.1 % of patients. It is a multifactorial event with variable degree of severity and clinical presentation. Cell derived vesicles are very small vesicles < 1μm released from cells in different conditions and for different purposes. They play an important role in cell signaling, adhesion and coagulation. Objective: to evaluate erythrocyte microparticles in patients with thalassemia. Patients and methods: Blood samples were collected from 50 thalassemic patients and 50 normal individuals. Platelet poor plasma was separated and used for analysis of erythrocyte microparticles by flow cytometry using CD235a. Results: A highly significant difference was observed between all groups in basic hematological parameters. The level of microparticles was significantly higher in patients with thalassemia and was higher in adult than in children. This high level is positively correlated with HbF levels and negatively correlated with Hb levels and Hb A levels. Conclusion: The levels of erythrocyte microparticles were higher in patients with thalassemia which may contribute to the hypercoagulable state of the disease. Further studies on medications that inhibit microparticles formation may be of value in prevention and treatment of thrombosis caused by these vesicles.