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Microsatellite instability (MSI) is involved in the pathogenesis of about 30% of endometrial cancer cases. In accumulating data from the past few years MSI is shown to have both clinical and prognostic value. In the present work we are discussing the components and molecular mechanisms of functioning of the mismatch repair system (MMR). MSI is a hallmark of endometrial tumors with DNA MMR deficiency. We summarized the main pathways for accumulating mutations in coding and non-coding DNA sequences, which is a result of errors during replication of microsatellite tandem repeats. A few studies rising valuable conclusions about the correlation between MSI and endometrial cancer are revised.

The aim of the study is to make retrospective analysis of 9 years experience in the feeding of praematuries and high risk newborn in that ward in First City Hospital-Sofia with formula milks "Nenatal" and "Nutrilon-premium". 721--42.4% from all babies in this period were feed with those formulas. With Nenatal only--11.8%, with Nutrilon-premium 88.2%. This the fact is due that all babies under 2000 gr. were fed with Nenatal, and after reaching 2000 gr.--with Nutrilon-premium. The results confirm that Nenatal is right formula for feeding of low and very low birth weight infant, due to its special content and qualities. The results from Nutrilon-premium illustrated that mean gain weight is the biggest in I grade of prematurity--33 grams, followed by matures--30 gr, after them II grade--29 gr., III grade--27 gr., IV grade--26 gr. As a conclusion we may say that mean gain weight for all groups is 29 grams. Consuming all gain weight of the babies feeding with Nutrilon-premium data appear that the biggest is in III of prematurity--1499 grams, followed by IV grade--1418 gr., I grade--1341 spama, II grade--1219 gr., and last matures--745 gr.