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Tandem bubble (TB) interactions have been shown to produce directional jets that can be used to create membrane poration on single cells. Jet speed and associated flow field produced around the TB have been postulated to play an important role in TB–induced bioeffects. In this study, dynamics of tandem bubble interaction in a microfluidic channel (25 µm in height) was analyzed by high-speed imaging and simulated using 3DYNAFS-BEM© (DYNAFLOW, INC.). The results suggest that jet size and geometry are primarily controlled by the maximum diameter of the first bubble (D1) while jet speed is about linearly correlated with maximum diameter of the second bubble (D2).

A 3‐D zero‐thickness shell model was developed to simulate the non‐spherical response of therapeutic encapsulated microbubbles subjected to ultrasound excitation. The 3‐D model was compared with previously developed models for validation. This model was then used to study the bubble break‐up during non‐spherical deformations resulting from the presence of a nearby solid wall. The effect of shell thickness and standoff distance to the solid wall on the bubble break‐up was studied parametrically. A diagram of bubble shapes was derived to categorize bubble forms at break‐up, and four zones were identified. The diagram indicates good conditions for drug and gene delivery.