The most recent Nijmegen extended-soft-core ESC16 model for the baryon-baryon (BB) interactions of the SU(3) flavor-octet of baryons (N, Λ, Σ, and Ξ) is presented. The ESC model ESC16, as well as its predecessors ESC08 and ESC04, describe the nucleon-nucleon (NN), hyperon-nucleon (YN), and hyperon-hyperon (YY) interactions in a unified way using broken SU(3) symmetry. In this paper we outline the differences between ESC16 and ESC08c.The parameters of the ESC models are established in a simultaneous fit to the NN and YN data, taking into account information about ΛΛ, ΞN, and Λ-hypernuclei in the form of constraints. In particular, the experimental indications for ΛΛ-attraction, Ξ-nuclear and Σ-nuclear well-depth were taken into account as much as possible. About 25 physical coupling parameters and 8 cut-off and diffractive masses, were searched. The obtained OBE-couplings and the F/(F+D) ratios can be well understood in the context of the quark-antiquark pair creation (QPC) mechanism.The fit of the ESC-models to the NN- and YN- scattering data with a single set of parameters has achieved excellent results for the NN and YN data, and for the YY data in accordance with the experimental indications for ΛΛ. In the case of the most recent ESC model, called ESC16, the achievements are: (i) For the selected 4313 pp and np scattering data with energies 0 ≤ Tlab ≤ 350 MeV, the model reaches a fit having χ2/Ndata = 1.10. (ii) The deuteron binding energy and all of the NN scattering lengths are fitted very nicely. (iii) The YN data are described very well with χ2 /Ndata = 1.11, giving at the same time good descriptions of the Λ, Σ, and Ξ nuclear well-depths. (iv) The model has no bound states for S = −1,−2,−3,−4. (v) The nuclear saturation, and well-depths UΣ, UΞ require important contributions from three-body forces.The most recent Nijmegen extended-soft-core ESC16 model for the baryon-baryon (BB) interactions of the SU(3) flavor-octet of baryons (N, Λ, Σ, and Ξ) is presented. The ESC model ESC16, as well as its predecessors ESC08 and ESC04, describe the nucleon-nucleon (NN), hyperon-nucleon (YN), and hyperon-hyperon (YY) interactions in a unified way using broken SU(3) symmetry. In this paper we outline the differences between ESC16 and ESC08c.The parameters of the ESC models are established in a simultaneous fit to the NN and YN data, taking into account information about ΛΛ, ΞN, and Λ-hypernuclei in the form of constraints. In particular, the experimental indications for ΛΛ-attraction, Ξ-nuclear and Σ-nuclear well-depth were taken into account as much as possible. About 25 physical coupling parameters and 8 cut-off and diffractive masses, were searched. The obtained OBE-couplings and the F/(F+D) ratios can be well understood in the context of the quark-antiquark pair creation (QPC) mechanism.The fit of the ESC-mod...