1. Microwave synthesis and antibacterial assay of new 1,3-thiazolidin-4-one derivatives based on 2-amino-5-mercapto-1,3,4-thiadiazole.
- Author
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Abbas, Haneen Hadi and Abood, Zeid Hassan
- Subjects
THIADIAZOLES ,MICROWAVES ,SCHIFF bases ,DIAZONIUM compounds ,ESCHERICHIA coli ,RESEARCH personnel - Abstract
2-Amino-5-mercapto-1,3,4-thiadiazole (1) was converted to the corresponding diazonium chloride salt which combined with salicylaldehyde through azo-coupling reaction affording azothiadiazolic aldehyde compound (2), then aldehyde group was condensed with substituted anilines (2-methoxyaniline, 2,4-dimethylaniline, 2,4-dichloroaniline, 4-chloroaniline, and 4-nitroaniline), respectively giving Schiff bases (3a-e). Imine compounds have been reacted with a-mercaptoacetic acid using microwave irradiation method affording the desired thiazolidinone derivatives (4a-e). Thiazolidines represent a very powerful kind of heterocyclic derivatives in pharmaceutical field and coerce researchers to reconnoiter novel drug candidates. Antibacterial study indicated that thiazolidinone derivatives (4a, 4d, and 4e) own effect greater than amoxicillin-clavulanate against Staphylococcus aurous, while compound (4e) appeared better activity than reference drug towards Escherichia coli. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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