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Particle acceleration driven by high-intensity laser systems is widely attracting interest as a potential alternative to conventional ion acceleration, including ion accelerator applications to tumor therapy. Recent works have shown that a high intensity laser pulse can produce single proton bunches of a high current and a short pulse duration. This unique feature of laser-ion acceleration can lead to progress in the development of novel ion sources. However, there has been no experimental study of the biological effects of laser-driven ion beams. We describe in this report the first demonstrated irradiation effect of laser-accelerated protons on human lung cancer cells. In-vitro A549 cells are irradiated with a proton dose of 20 Gy, resulting in a distinct formation of γ-H2AX foci as an indicator of DNA double-strand breaks. This is a pioneering result that points to future investigations of the radiobiological effects of laser-driven ion beams. The laser-driven ion beam is apotential excitation source for time-resolved determination of hydroxyl (OH) radical yield, which will explore relationship between the fundamental chemical reactions of radiation effects and consequent biological processes. [ABSTRACT FROM AUTHOR]

Assuming ⨍0(98O) and 𝒂0(980). are mainly qqq̅q̅ low mass scalar mesons and mixed with qq̅ high mass scalar mesons, we analyzed the mixing effects for 𝜙 → ⨍0(98O)γ, 𝜙→ 𝒂0(980)γ, ⨍0(98O) → γγ and 𝒂0(980) → γγ. Used the vector meson dominance model (VDM), these decay amplitudes are expressed by coupling parameters B describing the S(qqq̅q̅ scalar meson)-V(vector meson)-V(vector meson) coupling and B′ describing the S′(qq̅ scalar meson)-V-V coupling. If the magnitudes for B and B′ are ∼ 2.8GeV-1 and ∼ 12GeV-1, respectively, the mixing angle between 𝒂0(980) and 𝒂0(1450) are ∼ 9°, and the mixing parameter λ01 causing the mixing between I = 0 qqq̅q̅ state and qq̅ state is ∼ 0.24GeV2 , the experimental data for these radiative decays are interpreted consistently. [ABSTRACT FROM AUTHOR]

MIRRORCLE-6X, the unique portable synchrotrons, generates brilliant hard X-rays. The purpose of this study is to investigate the biological effects of synchrotron radiation on cancer cells to identify its effectiveness. A549 human lung adenocarcinoma and DU145 human prostate adenocarcinoma cells were used. We examined biological effects on cancer cells by colony formation assay, micronucleus assay, WST-1 method, and apoptosis detection of flow cytometry. Results of these assay revealed that the biological effects of X-ray generated from MIRRORCLE-6X on cancer cells are similar to those of 4 MV X- ray from linear accelerator (linac). [ABSTRACT FROM AUTHOR]