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The nanofluid technology has added significant contributions towards heat exchange increase and decrease in energy loss. This article focuses, to analyze the heat and mass transfer for two distinct hybrid nanofluids, namely (Ag-CuO/NE), (Ag-CuO/SE), under the impact of magnetic field and Rosseland radiation over a rotating cone embedded in the porous medium. The set of non-linear partial differential equations is derived with help of boundary layer approximation. A suitable and appropriate similarity set is used to obtain a dimensionless set of equations which, are then converted into ordinary differential equations. The problem is tackled numerically with the BVP-4c technique, keeping tolerance at 10−06. The influence of flow study parameters is discussed with help of graphical and tabulated data. The study shows that (Ag-CuO/NE) hybrid nanofluid has produced better heat and mass transfer rates as compared (Ag-CuO/SE) hybrid nanofluid. Therefore, the study suggests more frequent use of (Ag-CuO/NE).