1. Human T-lymphotropic virus type 1 and type 2 seroprevalence, incidence, and residual transfusion risk among blood donors in Brazil during 2007-2009.
- Author
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Carneiro-Proietti, Anna Bárbara F, Sabino, Ester C, Leão, Silvana, Salles, Nanci A, Loureiro, Paula, Sarr, Moussa, Wright, David, Busch, Michael, Proietti, Fernando A, Murphy, Edward L, and NHLBI Retrovirus Epidemiology Donor Study-II (Reds-II), International Component
- Subjects
NHLBI Retrovirus Epidemiology Donor Study-II (Reds-II) ,International Component ,Humans ,HTLV-I Infections ,HTLV-II Infections ,HTLV-I Antibodies ,HTLV-II Antibodies ,Mass Screening ,Immunoenzyme Techniques ,Blood Transfusion ,Donor Selection ,Sentinel Surveillance ,Incidence ,Prevalence ,Risk Factors ,Adolescent ,Adult ,Middle Aged ,Blood Donors ,Brazil ,Female ,Male ,Young Adult ,Transfusion Reaction ,Virology ,Clinical Sciences - Abstract
Human T-lymphotropic virus type 1/2 (HTLV-1/2) infection is endemic in Brazil but representative donor prevalence and incidence data are lacking. All blood donations (2007-2009) from three blood centers in Brazil were studied. Samples reactive on one HTLV screening test (EIA) were retested with a different EIA; dual EIA reactivity correlated strongly with a confirmatory Western blot. Prevalence, incidence, and residual transfusion risk were calculated. Among 281,760 first-time donors, 363 were positive for HTLV on both EIAs (135 per 10(5), 95% CI 122-150). Prevalence differed considerably by region, from 83 to 222 per 10(5). Overall incidence rate was 3.6/10(5) person-years and residual transfusion risk was 5.0/10(6) per blood unit transfused. The logistic regression model showed significant associations with: age [adjusted odds ratio (aOR)=5.23 for age 50+ vs.
- Published
- 2012