1. The therapeutic phase I trial of the recombinant native HIV-1 Tat protein.
- Author
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Ensoli B, Fiorelli V, Ensoli F, Lazzarin A, Visintini R, Narciso P, Di Carlo A, Monini P, Magnani M, and Garaci E
- Subjects
- AIDS Vaccines immunology, CD4 Lymphocyte Count, Double-Blind Method, HIV Antibodies biosynthesis, HIV Infections virology, Humans, Recombinant Proteins adverse effects, Recombinant Proteins immunology, Viral Load, tat Gene Products, Human Immunodeficiency Virus immunology, AIDS Vaccines adverse effects, HIV Infections immunology, HIV-1 immunology, tat Gene Products, Human Immunodeficiency Virus adverse effects
- Abstract
The native HIV-1 Tat protein was chosen as a vaccine candidate based on its key role in the virus life cycle and on the correlation of Tat-specific immune responses with the asymptomatic stage and lower disease progression rates, but also due to its sequence conservation amongst the various HIV clades as well as the adjuvant effects on dendritic cells. Safety, immunogenicity and efficacy data in monkeys support the development of this vaccine concept.
- Published
- 2008
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