1. Increasing age is associated with faster progression to neoplasms but not opportunistic infections in HIV-infected homosexual men.
- Author
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Veugelers PJ, Strathdee SA, Tindall B, Page KA, Moss AR, Schechter MT, Montaner JS, and van Griensven GJ
- Subjects
- Adult, Age Factors, Australia, British Columbia, Cohort Studies, HIV Seropositivity physiopathology, Humans, Incidence, Lymphoma complications, Male, Netherlands, Probability, Proportional Hazards Models, Risk Factors, San Francisco, AIDS-Related Opportunistic Infections epidemiology, HIV Seropositivity complications, Homosexuality, Male, Lymphoma epidemiology, Sarcoma, Kaposi epidemiology
- Abstract
Objective: To characterize the associations of age and progression rates to AIDS-defining neoplasms and opportunistic infections (OI) in HIV-infected homosexual men., Methods: Data from 407 homosexual men with documented dates of HIV seroconversion participating in cohort studies from four geographic locations were merged. Kaplan-Meier and Cox proportional hazards analyses were conducted with respect to the association of age with time from seroconversion to the first AIDS-defining neoplasm and OI., Results: Among the 407 participants, 139 (34%) were diagnosed with AIDS; 45 (11%) with neoplasms and 90 (22%) with OI. Older age at seroconversion was significantly associated with faster progression to neoplasms, but not to OI. For each 10-year increase in age the risk for neoplasms increased 1.65-fold [95% confidence interval (CI), 1.12-2.43], after adjustment for clinical treatments. For OI this risk estimate was 0.98 (95% CI, 0.72-1.34)., Conclusions: Increasing age is associated with faster progression to AIDS-defining neoplasms, but not with progression to OI. This has not been previously reported and may explain conflicting results in other studies among homosexual men that considered AIDS as a single entity. Our findings suggest that age and AIDS manifestations should be considered, particularly in the context of natural history studies, clinical trials and mathematical modelling.
- Published
- 1994
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