1. Respiratory viruses in HIV-infected patients with suspected respiratory opportunistic infection
- Author
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Erik Mossdorf, Michael Tamm, John-David Aubert, Caroline Tapparel, Laurent Kaiser, Rainer Weber, Pierre-Olivier Bridevaux, Sarra Inoubli, Paola M. Soccal, Jorge Garbino, University of Zurich, and Garbino, J
- Subjects
Male ,Rhinovirus ,Opportunistic infection ,viruses ,HIV Infections ,medicine.disease_cause ,10234 Clinic for Infectious Diseases ,Coronavirus OC43, Human ,Immunology and Allergy ,Prospective Studies ,Respiratory Tract Infections ,Coronavirus ,ddc:616 ,education.field_of_study ,medicine.diagnostic_test ,biology ,RNA, Messenger/analysis ,virus diseases ,Middle Aged ,Parainfluenza Virus 2, Human/genetics ,Parainfluenza Virus 2, Human ,Parainfluenza Virus 4, Human ,Infectious Diseases ,Rhinovirus/genetics ,Virus Diseases ,Viruses ,2723 Immunology and Allergy ,Respiratory virus ,Female ,Viral disease ,Bocavirus/genetics ,Viruses/genetics ,Bronchoalveolar Lavage Fluid ,Switzerland ,Adult ,Parainfluenza Virus 4, Human/genetics ,Immunology ,Population ,HIV Infections/complications ,610 Medicine & health ,Opportunistic Infections ,Bronchoalveolar Lavage Fluid/virology ,Respiratory Tract Infections/virology ,Virus ,Bocavirus ,Human metapneumovirus ,Metapneumovirus/genetics ,Opportunistic Infections/virology ,medicine ,Humans ,RNA, Messenger ,education ,Aged ,2403 Immunology ,Virus Diseases/virology ,2725 Infectious Diseases ,biology.organism_classification ,medicine.disease ,Virology ,Parainfluenza Virus 3, Human ,Bronchoalveolar lavage ,Coronavirus OC43, Human/genetics ,Parainfluenza Virus 3, Human/genetics ,Metapneumovirus - Abstract
OBJECTIVE: To assess the incidence and epidemiological pattern of respiratory viruses in HIV-infected patients and to evaluate their potential clinical impact. DESIGN AND METHODS: A prospective population-based cohort study was conducted at three Swiss university hospitals. Study participants were HIV-infected patients who underwent a bronchoalveolar lavage to rule out an opportunistic event. All bronchoalveolar lavage specimens were screened using a set of real-time reverse transcriptase-polymerase chain reaction assays targeting 17 different respiratory viruses. RESULTS: Between November 2003 and November 2006, 59 bronchoalveolar episodes from 55 HIV-infected patients were analysed. Eleven of 59 episodes (18.6%) were positive for at least one respiratory virus. Coronavirus OC43 was identified in three cases (27.3%) followed by influenza A in two (18.2%). Parainfluenza virus (PIV) 2, PIV 3, PIV 4, bocavirus, human rhinovirus A and human metapneumovirus were each identified in one case (9%). In the majority of these cases (63.6%) no other concomitant microorganism was isolated. CONCLUSIONS: Clinical investigation of respiratory viral infections in HIV-infected patients should not be restricted to prototype viruses and also need to target all the different family of viruses as it seems likely that these viruses contribute to pulmonary complications and morbidity in this population.
- Published
- 2008