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Start Over Author "Sophie Capdepont" Journal aids (london, england)
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1. Virological characterization of an infection with a dual-tropic, multidrug-resistant HIV-1 and further evolution on antiretroviral therapy

Author

Wassila Carpentier, Olivia Peuchant, Bernard Masquelier, Jean-Luc Taupin, Eoin Coakley, Hervé Fleury, François Dabis, Sophie Capdepont, Yolanda Lie, and Didier Neau

Subjects
Adult, Male, Genotype, Receptors, CCR5, Immunology, HIV Infections, Virus, Acquired immunodeficiency syndrome (AIDS), Drug Resistance, Multiple, Viral, medicine, Immunology and Allergy, Humans, Sida, Tropism, biology, Viral Load, medicine.disease, biology.organism_classification, Virology, CD4 Lymphocyte Count, Multiple drug resistance, Infectious Diseases, Anti-Retroviral Agents, Lentivirus, HIV-1, Viral disease, Viral load
Abstract

We studied a case of recent infection with multidrug-resistant (MDR) HIV-1. Over 16 months off-therapy, the CD4 cell count decreased from 419 to 184 cells/mul. Antiretroviral therapy (ART) then led to an incomplete virological response but to an immunological benefit, concurrently with a shift to CCR5-only tropism and a reduction in replication capacity. ART, even if suboptimal, can be of interest in the case of MDR virus infection.

Published
2006

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