1. Association of marijuana, tobacco and alcohol use with estimated glomerular filtration rate in women living with HIV and women without HIV
- Author
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Fisher, Molly C, Hoover, Donald R, Shi, Qiuhu, Sharma, Anjali, Estrella, Michelle M, Adimora, Adaora, Alcaide, Maria, Collins, Lauren F, French, Audrey, Gao, Wei, Koletar, Susan L, Mcfarlane, Samy I, Mckay, Heather, Dionne, Jodie A, Palella, Frank, Sarkar, Sudipa, Spence, Amanda, Witt, Mallory D, and Ross, Michael J
- Subjects
Biomedical and Clinical Sciences ,Public Health ,Health Sciences ,Clinical Sciences ,HIV/AIDS ,Drug Abuse (NIDA only) ,Sexually Transmitted Infections ,Prevention ,Cannabinoid Research ,Women's Health ,Alcoholism ,Alcohol Use and Health ,Infectious Diseases ,Substance Misuse ,Kidney Disease ,3.1 Primary prevention interventions to modify behaviours or promote wellbeing ,Renal and urogenital ,Good Health and Well Being ,Humans ,Female ,United States ,Glomerular Filtration Rate ,Cannabis ,HIV Infections ,Prospective Studies ,Substance-Related Disorders ,alcohol ,estimated glomerular filtration rate ,HIV ,kidney ,marijuana ,tobacco ,women ,Biological Sciences ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Virology ,Biomedical and clinical sciences ,Health sciences - Abstract
ObjectiveMarijuana, tobacco and alcohol use are prevalent among people with HIV and may adversely affect kidney function in this population. We determined the association of use of these substances with estimated glomerular filtration rate (eGFR) among women with HIV (WWH) and women without HIV.DesignWe undertook a repeated measures study of 1043 WWH and 469 women without HIV within the United States Women's Interagency HIV Study, a multicenter, prospective cohort of HIV-seropositive and HIV-seronegative women.MethodsWe quantified substance exposures using semi-annual questionnaires. Using pooled eGFR data from 2009 to 2019, we used linear regression models with multivariable generalized estimating equations to ascertain associations between current and cumulative substance use exposures with eGFR, adjusting for sociodemographics, chronic kidney disease risk factors and HIV-related factors.ResultsMarijuana use of 1-14 days/month versus 0 days/month was associated with 3.34 ml/min per 1.73 m 2 [95% confidence interval (CI) -6.63, -0.06] lower eGFR and marijuana use of >0.02-1.6 marijuana-years versus 0-0.2 marijuana-years was associated with 3.61 ml/min per 1.73 m 2 (95% CI -5.97, -1.24) lower eGFR. Tobacco use was not independently associated with eGFR. Alcohol use of seven or more drinks/week versus no drinks/week was associated with 5.41 ml/min per 1.73 m 2 (95% CI 2.34, 8.48) higher eGFR and alcohol use of >0.7-4.27 drink-years and >4.27 drink-years versus 0-0.7 drink-years were associated with 2.85 ml/min per 1.73 m 2 (95% CI 0.55, 5.15) and 2.26 ml/min per 1.73 m 2 (95% CI 0.33, 4.20) higher eGFR, respectively.ConclusionAmong a large cohort of WWH and women without HIV, marijuana use was associated with a lower eGFR while alcohol use was associated with a higher eGFR.
- Published
- 2023