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This paper describes the transformation of a traditional in silico classification network into an optical fully convolutional neural network with high-resolution feature maps and kernels. When using the free-space 4f system to accelerate the inference speed of neural networks, higher resolutions of feature maps and kernels can be used without the loss in frame rate. We present FatNet for the classification of images, which is more compatible with free-space acceleration than standard convolutional classifiers. It neglects the standard combination of convolutional feature extraction and classifier dense layers by performing both in one fully convolutional network. This approach takes full advantage of the parallelism in the 4f free-space system and performs fewer conversions between electronics and optics by reducing the number of channels and increasing the resolution, making this network faster in optics than off-the-shelf networks. To demonstrate the capabilities of FatNet, it was trained with the CIFAR100 dataset on GPU and the simulator of the 4f system. A comparison of the results against ResNet-18 shows 8.2 times fewer convolution operations at the cost of only 6% lower accuracy. This demonstrates that the optical implementation of FatNet results in significantly faster inference than the optical implementation of the original ResNet-18. These are promising results for the approach of training deep learning with high-resolution kernels in the direction toward the upcoming optics era. [ABSTRACT FROM AUTHOR]

Automating the analysis of digital microscopic images to identify the cell sub-types or the presence of illness has assumed a great importance since it aids the laborious manual process of review and diagnosis. In this paper, we have focused on the analysis of white blood cells. They are the body’s main defence against infections and diseases and, therefore, their reliable classification is very important. Current systems for leukocyte analysis are mainly dedicated to: counting, sub-types classification, disease detection or classification. Although these tasks seem very different, they share many steps in the analysis process, especially those dedicated to the detection of cells in blood smears. A very accurate detection step gives accurate results in the classification of white blood cells. Conversely, when detection is not accurate, it can adversely affect classification performance. However, it is very common in real-world applications that work on inaccurate or non-accurate regions. Many problems can affect detection results. They can be related to the quality of the blood smear images, e.g., colour and lighting conditions, absence of standards, or even density and presence of overlapping cells. To this end, we performed an in-depth investigation of the above scenario, simulating the regions produced by detection-based systems. We exploit various image descriptors combined with different classifiers, including CNNs, in order to evaluate which is the most suitable in such a scenario, when performing two different tasks: Classification of WBC subtypes and Leukaemia detection. Experimental results have shown that Convolutional Neural Networks are very robust in such a scenario, outperforming common machine learning techniques combined with hand-crafted descriptors. However, when exploiting appropriate images for model training, even simpler approaches can lead to accurate results in both tasks. [ABSTRACT FROM AUTHOR]