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The article aims to present a cyber–physical system (CPS) to support the cultivation of aquaculture in a closed aquaponic system using the deep-water culture (DWC) method. The CPS uses precision sensors as TriOxmatic 700 IQ (for dissolved oxygen and water temperature), AmmoLyt Plus 700 IQ (for ammonium), NiCaVis 701 IQ NI (for nitrites and nitrates), SensoLyt® 700 IQ (for pH), and SL-M5 (for water level). It is built with a Raspberry Pi 4, 8 GB as a server, OpenHAB 3.0 software, and other specialized software for measuring water parameters. Some of the parameters are maintained completely autonomously, while others are indirectly controlled. Basic knowledge of hydroponics and aquaculture is required to set up the system, but day-to-day maintenance can be carried out by employees who receive instructions from the CPS. A method for the physical modification of the fish tank surface by using laser processing is proposed. This results in a change in surface topography (creating diverse microstructure patterns) and its roughness, which is of crucial importance for the bacterial adhesion mechanism. more...