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Parkinson's disease (PD) is the second neurodegenerative disease in the world. The pathological characteristics of PD are degeneration, loss and death of dopaminergic neurons in the substantia nigra of the midbrain. At present, most scholars believe that the main pathogenesis of PD is a-synuclein aggregation, oxidative stress, mitochondrial dysfunction and neuroinflammatory reaction. More and more studies have demonstrated that ferroptosis plays an important role in the occurrence and development of PD. Ferroptosis is a new type of cell death that is significantly different from traditional apoptosis, scorching and necrosis. Its main feature is iron-dependent lipid peroxidation. Some studies have found that the efficacy of acupuncture and moxibustion in the treatment of PD may be related to the regulation of ferroptosis. Therefore, this study mainly discusses the occurrence and development mechanism of ferroptosis and its role in PD, and the possible mechanism of acupuncture and moxibustion in the treatment of PD dopaminergic neurons, so as to provide theoretical basis for acupuncture and moxibustion in the treatment of PD. [ABSTRACT FROM AUTHOR]