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Your search keyword '"transfer RNA-derived small RNA"' showing total 2 results
Start Over Descriptor "transfer RNA-derived small RNA" Journal aging cell
2 results on '"transfer RNA-derived small RNA"'

1. Altered sperm tsRNAs in aged male contribute to anxiety‐like behavior in offspring.

Author

Guo, Yi, Bai, Dandan, Liu, Wenqiang, Liu, Yingdong, Zhang, Yalin, Kou, Xiaochen, Chen, Jiayu, Wang, Hong, Teng, Xiaoming, Zuo, Ji, and Gao, Shaorong

Subjects
*ANXIETY, *MATERNALLY acquired immunity, *OLDER people, *SPERMATOZOA, *NON-coding RNA, *CEREBRAL cortex
Abstract

Parental age at first pregnancy is increasing worldwide. The offspring of aged father has been associated with higher risk of several neuropsychiatric disorders, such as schizophrenia and autism, but the underlying mechanism remains elusive. Here we report that advanced paternal age in mice alters the profile of transfer RNA‐derived small RNAs (tsRNAs). Injection of sperm tsRNAs from aged male mice into zygotes induced anxiety‐like behaviors in F1 males. RNA sequencing of the cerebral cortex and hippocampus of those F1 male mice altered the gene expression of dopaminergic synapse and neurotrophin. tsRNAs from aged male mice injection also altered the neuropsychiatry‐related gene expression in two‐cell and blastocyst stage embryos. More importantly, the sperm tsRNA profile changes significantly during aging in human. The up‐regulated sperm tsRNA target genes were involved in neurogenesis and nervous system development. These results suggest that aging‐related changes of sperm tsRNA may contribute to the intergenerational transmission of behavioral traits. [ABSTRACT FROM AUTHOR]

Published
2021
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2. Altered sperm tsRNAs in aged male contribute to anxiety‐like behavior in offspring

Author

Wenqiang Liu, Yi Guo, Yalin Zhang, Jiayu Chen, Dandan Bai, Xiaochen Kou, Yingdong Liu, Shaorong Gao, Hong Wang, Ji Zuo, and Xiaoming Teng

Subjects
Male, Aging, Offspring, transfer RNA‐derived small RNA, Hippocampus, Anxiety, sperm, Andrology, Mice, RNA, Transfer, Gene expression, pre‐implantation embryo, Animals, Original Paper, biology, offspring, Neurogenesis, Embryo, Cell Biology, Sperm, Original Papers, Spermatozoa, Mice, Inbred C57BL, Dopaminergic synapse, biology.protein, Female, Advanced paternal age, Neurotrophin
Abstract

Parental age at first pregnancy is increasing worldwide. The offspring of aged father has been associated with higher risk of several neuropsychiatric disorders, such as schizophrenia and autism, but the underlying mechanism remains elusive. Here we report that advanced paternal age in mice alters the profile of transfer RNA‐derived small RNAs (tsRNAs). Injection of sperm tsRNAs from aged male mice into zygotes induced anxiety‐like behaviors in F1 males. RNA sequencing of the cerebral cortex and hippocampus of those F1 male mice altered the gene expression of dopaminergic synapse and neurotrophin. tsRNAs from aged male mice injection also altered the neuropsychiatry‐related gene expression in two‐cell and blastocyst stage embryos. More importantly, the sperm tsRNA profile changes significantly during aging in human. The up‐regulated sperm tsRNA target genes were involved in neurogenesis and nervous system development. These results suggest that aging‐related changes of sperm tsRNA may contribute to the intergenerational transmission of behavioral traits., Advanced paternal age in mice and human alters the profile of transfer RNA‐derived small RNAs (tsRNAs). Injection of sperm tsRNA from aged male mice into zygotes induced anxiety‐like behaviors in F1 males and also altered the neuropsychiatry‐related gene expression in two‐cell and blastocyst embryos. These results suggest that aging‐related changes of sperm tsRNA may contribute to the intergenerational transmission of behavioral traits.

Published
2021

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