1. Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited
- Author
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Willemijn M. Passtoors, Jeanine J. Houwing-Duistermaat, Kaare Christensen, Diana van Heemst, David A. Gunn, Anton J. N. de Craen, Joris Deelen, P. Eline Slagboom, Eco J. C. de Geus, André G. Uitterlinden, Markus Perola, Lene Christiansen, Henning Tiemeier, H. Eka D. Suchiman, Maris Kuningas, Cornelia M. van Duijn, Quinta Helmer, Fernando Rivadeneira, Dennis Kremer, Frans van der Ouderaa, Nico Lakenberg, Rudi G. J. Westendorp, Bastiaan T. Heijmans, Marian Beekman, Dorret I. Boomsma, Erik B. van den Akker, Ruud van der Breggen, and Hae-Won Uh
- Subjects
Genetics ,0303 health sciences ,Aging ,education.field_of_study ,Linkage disequilibrium ,media_common.quotation_subject ,Population ,Longevity ,Locus (genetics) ,Single-nucleotide polymorphism ,Genome-wide association study ,Cell Biology ,Biology ,03 medical and health sciences ,Rotterdam Study ,0302 clinical medicine ,Allele ,education ,030217 neurology & neurosurgery ,030304 developmental biology ,media_common - Abstract
By studying the loci that contribute to human longevity, we aim to identify mechanisms that contribute to healthy aging. To identify such loci, we performed a genome-wide association study (GWAS) comparing 403 unrelated nonagenarians from long-living families included in the Leiden Longevity Study (LLS) and 1670 younger population controls. The strongest candidate SNPs from this GWAS have been analyzed in a meta-analysis of nonagenarian cases from the Rotterdam Study, Leiden 85-plus study, and Danish 1905 cohort. Only one of the 62 prioritized SNPs from the GWAS analysis (P
- Published
- 2011