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Your search keyword '"Evans, Daniel S"' showing total 5 results
Start Over Author "Evans, Daniel S" Journal aging cell
5 results on '"Evans, Daniel S"'

1. Expression of mitochondrial oxidative stress response genes in muscle is associated with mitochondrial respiration, physical performance, and muscle mass in the Study of Muscle, Mobility, and Aging

Author

Tranah, Gregory J., primary, Barnes, Haley N., additional, Cawthon, Peggy M., additional, Coen, Paul M., additional, Esser, Karyn A., additional, Hepple, Russell T., additional, Huo, Zhiguang, additional, Kramer, Philip A., additional, Toledo, Frederico G. S., additional, Zhang, Xiping, additional, Wu, Kevin, additional, Wolff, Christopher A., additional, Evans, Daniel S., additional, and Cummings, Steven R., additional

Published
2024
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2. Higher expression of denervation‐responsive genes is negatively associated with muscle volume and performance traits in the study of muscle, mobility, and aging (SOMMA)

Author

Lukasiewicz, Cole J., primary, Tranah, Gregory J., additional, Evans, Daniel S., additional, Coen, Paul M., additional, Barnes, Haley N., additional, Huo, Zhiguang, additional, Esser, Karyn A., additional, Zhang, Xiping, additional, Wolff, Christopher, additional, Wu, Kevin, additional, Lane, Nancy E., additional, Kritchevsky, Steven B., additional, Newman, Anne B., additional, Cummings, Steven R., additional, Cawthon, Peggy M., additional, and Hepple, Russell T., additional

Published
2024
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3. Autophagy gene expression in skeletal muscle of older individuals is associated with physical performance, muscle volume and mitochondrial function in the study of muscle, mobility and aging (SOMMA)

Author

Coen, Paul M., primary, Huo, Zhiguang, additional, Tranah, Gregory J., additional, Barnes, Haley N., additional, Zhang, Xiping, additional, Wolff, Christopher A., additional, Wu, Kevin, additional, Cawthon, Peggy M., additional, Hepple, Russell T., additional, Toledo, Frederico G. S., additional, Evans, Daniel S., additional, Santiago‐Fernández, Olaya, additional, Cuervo, Ana Maria, additional, Kritchevsky, Stephen B., additional, Newman, Anne B., additional, Cummings, Steven R., additional, and Esser, Karyn A., additional

Published
2024
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4. GWAS analysis of handgrip and lower body strength in older adults in the CHARGE consortium.

Author

Matteini, Amy M, Tanaka, Toshiko, Karasik, David, Atzmon, Gil, Chou, Wen-Chi, Eicher, John D, Johnson, Andrew D, Arnold, Alice M, Callisaya, Michele L, Davies, Gail, Evans, Daniel S, Holtfreter, Birte, Lohman, Kurt, Lunetta, Kathryn L, Mangino, Massimo, Smith, Albert V, Smith, Jennifer A, Teumer, Alexander, Yu, Lei, Arking, Dan E, Buchman, Aron S, Chibinik, Lori B, De Jager, Philip L, Evans, Denis A, Faul, Jessica D, Garcia, Melissa E, Gillham-Nasenya, Irina, Gudnason, Vilmundur, Hofman, Albert, Hsu, Yi-Hsiang, Ittermann, Till, Lahousse, Lies, Liewald, David C, Liu, Yongmei, Lopez, Lorna, Rivadeneira, Fernando, Rotter, Jerome I, Siggeirsdottir, Kristin, Starr, John M, Thomson, Russell, Tranah, Gregory J, Uitterlinden, André G, Völker, Uwe, Völzke, Henry, Weir, David R, Yaffe, Kristine, Zhao, Wei, Zhuang, Wei Vivian, Zmuda, Joseph M, Bennett, David A, Cummings, Steven R, Deary, Ian J, Ferrucci, Luigi, Harris, Tamara B, Kardia, Sharon LR, Kocher, Thomas, Kritchevsky, Stephen B, Psaty, Bruce M, Seshadri, Sudha, Spector, Timothy D, Srikanth, Velandai K, Windham, B Gwen, Zillikens, M Carola, Newman, Anne B, Walston, Jeremy D, Kiel, Douglas P, and Murabito, Joanne M

Subjects
Humans, Hand Strength, Cohort Studies, Reproducibility of Results, Chromatin Immunoprecipitation, Epigenesis, Genetic, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Adult, Aged, Muscle Strength, Genome-Wide Association Study, Molecular Sequence Annotation, SNP, aging, genomewide association, meta-analysis, muscle strength, older adults, Epigenesis, Genetic, Polymorphism, Single Nucleotide, Developmental Biology, Medical and Health Sciences, Biological Sciences
Abstract

Decline in muscle strength with aging is an important predictor of health trajectory in the elderly. Several factors, including genetics, are proposed contributors to variability in muscle strength. To identify genetic contributors to muscle strength, a meta-analysis of genomewide association studies of handgrip was conducted. Grip strength was measured using a handheld dynamometer in 27 581 individuals of European descent over 65 years of age from 14 cohort studies. Genomewide association analysis was conducted on ~2.7 million imputed and genotyped variants (SNPs). Replication of the most significant findings was conducted using data from 6393 individuals from three cohorts. GWAS of lower body strength was also characterized in a subset of cohorts. Two genomewide significant (P-value< 5 × 10(-8) ) and 39 suggestive (P-value< 5 × 10(-5) ) associations were observed from meta-analysis of the discovery cohorts. After meta-analysis with replication cohorts, genomewide significant association was observed for rs752045 on chromosome 8 (β = 0.47, SE = 0.08, P-value = 5.20 × 10(-10) ). This SNP is mapped to an intergenic region and is located within an accessible chromatin region (DNase hypersensitivity site) in skeletal muscle myotubes differentiated from the human skeletal muscle myoblasts cell line. This locus alters a binding motif of the CCAAT/enhancer-binding protein-β (CEBPB) that is implicated in muscle repair mechanisms. GWAS of lower body strength did not yield significant results. A common genetic variant in a chromosomal region that regulates myotube differentiation and muscle repair may contribute to variability in grip strength in the elderly. Further studies are needed to uncover the mechanisms that link this genetic variant with muscle strength.

Published
2016

5. The FoxO3 gene and cause‐specific mortality

Author

Willcox, Bradley J., primary, Tranah, Gregory J., additional, Chen, Randi, additional, Morris, Brian J., additional, Masaki, Kamal H., additional, He, Qimei, additional, Willcox, D. Craig, additional, Allsopp, Richard C., additional, Moisyadi, Stefan, additional, Poon, Leonard W., additional, Rodriguez, Beatriz, additional, Newman, Anne B., additional, Harris, Tamara B., additional, Cummings, Steven R., additional, Liu, Yongmei, additional, Parimi, Neeta, additional, Evans, Daniel S., additional, Davy, Phil, additional, Gerschenson, Mariana, additional, and Donlon, Timothy A., additional

Published
2016
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