1. Development and validation of a risk score for predicting mortality after resection of primary hepatocellular carcinoma
- Author
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Xiang-Qing Hou, Xing-Kai Kang, Bin-Bin Cai, Weiming Wang, Xiangxiang Xu, and Xiang Zhou
- Subjects
Male ,Aging ,medicine.medical_specialty ,Carcinoma, Hepatocellular ,Kaplan-Meier Estimate ,Risk Assessment ,Resection ,Hosmer–Lemeshow test ,Quality of life ,Goodness of fit ,Risk Factors ,Internal medicine ,PHCC ,medicine ,Hepatectomy ,Humans ,Neoplasm Staging ,Proportional Hazards Models ,Retrospective Studies ,Framingham Risk Score ,Receiver operating characteristic ,business.industry ,Mortality rate ,Liver Neoplasms ,Cell Biology ,Middle Aged ,medicine.disease ,Prognosis ,mortality ,Treatment Outcome ,Liver ,ROC Curve ,Hepatocellular carcinoma ,Female ,business ,X-tile ,Hosmer-Lemeshow ,Research Paper ,Follow-Up Studies - Abstract
Background: Primary hepatocellular carcinoma (PHCC) has a poor prognosis and high short-term mortality rate, even after resection. Thus, early diagnosis in PHCC cases can help improve quality of life via personalized management strategies. Results: The risk score system (RSS) were classified as low risk (10 points). The areas under the receiver operating characteristic curves were 0.80 in the training cohort and 0.69 in the validation cohort, which indicated satisfactory prognostic performance. The Hosmer-Lemeshow goodness of fit test (P>0.05) revealed consistent performance in both groups. The concordance index (C-index: 0.663, 95% CI: 0.618–0.708) revealed excellent discrimination and good calibration in the validation cohort. Conclusions: This simple RSS, which is based on clinical and laboratory data from patients undergoing resection of PHCC, might allow clinicians and medical staff to better manage PHCC. Materials and Methods: A total of 672 PHCC cases were retrospectively obtained from the First Affiliated Hospital of Wenzhou Medical University between January 2007 and February 2015. Cox proportional hazard models were used to identify independent predictors of mortality. Kaplan-Meier curves and the log-rank test were used to examine the relationships between the prognostic factors and overall mortality.
- Published
- 2020