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10 results on '"CAPRI, MIRIAM"'

1. Circulating perilipin 2 levels are associated with fat mass, inflammatory and metabolic markers and are higher in women than men

Author

Conte, Maria, primary, Santoro, Aurelia, additional, Collura, Salvatore, additional, Martucci, Morena, additional, Battista, Giuseppe, additional, Bazzocchi, Alberto, additional, Morsiani, Cristina, additional, Sevini, Federica, additional, Capri, Miriam, additional, Monti, Daniela, additional, Franceschi, Claudio, additional, and Salvioli, Stefano, additional

Published
2021
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3. Erratum: A meta-analysis on age-associated changes in blood DNA methylation: results from an original analysis pipeline for Infinium 450k data

Author

Bacalini, Maria Giulia, primary, Boattini, Alessio, additional, Gentilini, Davide, additional, Giampieri, Enrico, additional, Pirazzini, Chiara, additional, Giuliani, Cristina, additional, Fontanesi, Elisa, additional, Remondini, Daniel, additional, Capri, Miriam, additional, Del Rio, Alberto, additional, Luiselli, Donata, additional, Vitale, Giovanni, additional, Mari, Daniela, additional, Castellani, Gastone, additional, Di Blasio, Anna Maria, additional, Salvioli, Stefano, additional, Franceschi, Claudio, additional, and Garagnani, Paolo, additional

Published
2016
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4. A meta-analysis on age-associated changes in blood DNA methylation: results from an original analysis pipeline for Infinium 450k data

Author

Bacalini, Maria Giulia, primary, Boattini, Alessio, additional, Gentilini, Davide, additional, Giampieri, Enrico, additional, Pirazzini, Chiara, additional, Giuliani, Cristina, additional, Fontanesi, Elisa, additional, Remondini, Daniel, additional, Capri, Miriam, additional, Del Rio, Alberto, additional, Luiselli, Donata, additional, Vitale, Giovanni, additional, Mari, Daniela, additional, Castellani, Gastone, additional, Di Blasio, Anna Maria, additional, Salvioli, Stefano, additional, Franceschi, Claudio, additional, and Garagnani, Paolo, additional

Published
2015
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5. Mitochondria hyperfusion and elevated autophagic activity are key mechanisms for cellular bioenergetic preservation in centenarians

Author

Sgarbi, Gianluca, primary, Matarrese, Paola, additional, Pinti, Marcello, additional, Lanzarini, Catia, additional, Ascione, Barbara, additional, Gibellini, Lara, additional, Dika, Emi, additional, Patrizi, Annalisa, additional, Tommasino, Chiara, additional, Capri, Miriam, additional, Cossarizza, Andrea, additional, Baracca, Alessandra, additional, Lenaz, Giorgio, additional, Solaini, Giancarlo, additional, Franceschi, Claudio, additional, Malorni, Walter, additional, and Salvioli, Stefano, additional

Published
2014
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6. Serum profiling of healthy aging identifies phospho- and sphingolipid species as markers of human longevity

Author

Montoliu, Ivan, primary, Scherer, Max, additional, Beguelin, Fiona, additional, DaSilva, Laeticia, additional, Mari, Daniela, additional, Salvioli, Stefano, additional, Martin, François-Pierre J., additional, Capri, Miriam, additional, Bucci, Laura, additional, Ostan, Rita, additional, Garagnani, Paolo, additional, Monti, Daniela, additional, Biagi, Elena, additional, Brigidi, Patrizia, additional, Kussmann, Martin, additional, Rezzi, Serge, additional, Franceschi, Claudio, additional, and Collino, Sebastiano, additional

Published
2014
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7. Identification of a DNA methylation signature in blood cells from persons with Down Syndrome

Author

Bacalini, Maria Giulia, primary, Gentilini, Davide, additional, Boattini, Alessio, additional, Giampieri, Enrico, additional, Pirazzini, Chiara, additional, Giuliani, Cristina, additional, Fontanesi, Elisa, additional, Scurti, Maria, additional, Remondini, Daniel, additional, Capri, Miriam, additional, Cocchi, Guido, additional, Ghezzo, Alessandro, additional, Del Rio, Alberto, additional, Luiselli, Donata, additional, Vitale, Giovanni, additional, Mari, Daniela, additional, Castellani, Gastone, additional, Fraga, Mario, additional, Di Blasio, Anna Maria, additional, Salvioli, Stefano, additional, Franceschi, Claudio, additional, and Garagnani, Paolo, additional

Published
2014
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8. Centenarians as super-controls to assess the biological relevance of genetic risk factors for common age-related diseases: A proof of principle on type 2 diabetes

Author

Garagnani, Paolo, primary, Giuliani, Cristina, additional, Pirazzini, Chiara, additional, Olivieri, Fabiola, additional, Bacalini, Maria Giulia, additional, Ostan, Rita, additional, Mari, Daniela, additional, Passarino, Giuseppe, additional, Monti, Daniela, additional, Bonfigli, Anna Rita, additional, Boemi, Massimo, additional, Ceriello, Antonio, additional, Genovese, Stefano, additional, Sevini, Federica, additional, Luiselli, Donata, additional, Tieri, Paolo, additional, Capri, Miriam, additional, Salvioli, Stefano, additional, Vijg, Jan, additional, Suh, Yousin, additional, Delledonne, Massimo, additional, Testa, Roberto, additional, and Franceschi, Claudio, additional

Published
2013
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9. Space/Population and Time/Age in DNA methylation variability in humans: a study on IGF2/H19 locus in different Italian populations and in mono- and di-zygotic twins of different age

Author

Pirazzini, Chiara, primary, Giuliani, Cristina, additional, Bacalini, Maria Giulia, additional, Boattini, Alessio, additional, Capri, Miriam, additional, Fontanesi, Elisa, additional, Marasco, Elena, additional, Mantovani, Vilma, additional, Pierini, Michela, additional, Pini, Elisa, additional, Luiselli, Donata, additional, Franceschi, Claudio, additional, and Garagnani, Paolo, additional

Published
2012
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10. Identification of a DNA methylation signature in blood cells from persons with Down Syndrome.

Author

Bacalini MG, Gentilini D, Boattini A, Giampieri E, Pirazzini C, Giuliani C, Fontanesi E, Scurti M, Remondini D, Capri M, Cocchi G, Ghezzo A, Del Rio A, Luiselli D, Vitale G, Mari D, Castellani G, Fraga M, Di Blasio AM, Salvioli S, Franceschi C, and Garagnani P

Subjects
Epigenesis, Genetic, Female, Gene Ontology, Humans, Leukocyte Count, Male, DNA Methylation, Down Syndrome metabolism, Leukocytes metabolism
Abstract

Down Syndrome (DS) is characterized by a wide spectrum of clinical signs, which include segmental premature aging of central nervous and immune systems. Although it is well established that the causative defect of DS is the trisomy of chromosome 21, the molecular bases of its phenotype are still largely unknown. We used the Infinium HumanMethylation450 BeadChip to investigate DNA methylation patterns in whole blood from 29 DS persons, using their relatives (mothers and unaffected siblings) as controls. This family-based model allowed us to monitor possible confounding effects on DNA methylation patterns deriving from genetic and environmental factors. Although differentially methylated regions (DMRs) displayed a genome-wide distribution, they were enriched on chromosome 21. DMRs mapped in genes involved in developmental functions, including embryonic development (HOXA family) and haematological (RUNX1 and EBF4) and neuronal (NCAM1) development. Moreover, genes involved in the regulation of chromatin structure (PRMD8, KDM2B, TET1) showed altered methylation. The data also showed that several pathways are affected in DS, including PI3K-Akt signaling. In conclusion, we identified an epigenetic signature of DS that sustains a link between developmental defects and disease phenotype, including segmental premature aging.

Published
2015
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