1. Coumarin toxicity in different strains of mice
- Author
-
W. Endell and G. Seidel
- Subjects
Pharmacology ,Male ,Mice, Inbred C3H ,Immunology ,Pharmacology toxicology ,Context (language use) ,Metabolism ,Toxicology ,Coumarin ,Coumarin metabolism ,Lethal Dose 50 ,chemistry.chemical_compound ,Mice ,Animal model ,chemistry ,Species Specificity ,Coumarins ,Mice, Inbred DBA ,Toxicity ,Animals ,heterocyclic compounds ,Pharmacology (medical) ,Aspartate Aminotransferases ,Chemical and Drug Induced Liver Injury - Abstract
The general toxic effects of coumarin, as well as coumarin hepatotoxicity were found to be less in DBA/2J mice than in CH3/HeJ mice. Thess results are discussed in the context of a strain-specific coumarin metabolism and indicate the need for suitable animal models to assess the toxicity of a given substance in man.
- Published
- 1978