1. In vivo inhibition of plasma protein leakage andSalmonella enteritidis—induced mortality in the rat by a specific paf-acether antagonist: BN 52021
- Author
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A. Etienne, Brigitte Spinnewyn, C. Soulard, F. Clostre, F. Hecquet, and Pierre Braquet
- Subjects
Male ,medicine.drug_class ,Immunology ,Pharmacology ,Toxicology ,Capillary Permeability ,Lactones ,In vivo ,medicine ,Animal mortality ,Animals ,Pharmacology (medical) ,Platelet Activating Factor ,Salmonella Infections, Animal ,biology ,Plant Extracts ,Ginkgo biloba ,Septic shock ,Chemistry ,Antagonist ,Rats, Inbred Strains ,Blood Proteins ,biology.organism_classification ,medicine.disease ,Receptor antagonist ,Shock, Septic ,Blood proteins ,Rats ,Ginkgolides ,Salmonella enteritidis ,Biochemistry ,biology.protein ,Cyclooxygenase ,Diterpenes - Abstract
The effects of BN 52021, a new specific paf-acether receptor antagonist and the total Ginkgo Biloba extract (GBE 761) from which this product was isolated, were studied in the rat on paf-acether-induced permeability and cell number changes and on endotoxin-induced lethality. Their activities were compared to those of cyclooxygenase, 5-lipoxygenase and phospholipase A2 inhibitors. BN 52021 given s.c. or orally exerted a dose-related inhibition of paf-acether deleterious effects as well as of endotoxin lethality whereas the other drugs tested were poorly effective. These results strongly suggest paf-acether involvement in endotoxic and septic shock.
- Published
- 1986
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