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This study explores the predictors of cervical cancer (CC) knowledge and attitude among Saudi women in Najran city. A descriptive cross-sectional study was conducted in Najran/ KSA to recruit 1085 participants from June to September 2021. An online selfreported questionnaire was used for data collection; it consisted of basic data and health history, a CC knowledge quiz, and a CC attitude scale. Data analysis was performed using the Statistical IBM software, version 23 (IBM Corp., Armonk, N.Y., USA)'. The findings revealed that more than half of the participants (57.7%) had insufficient knowledge regarding CC. At the same time, 59.4% of them had a positive attitude toward CC screening. According to binary logistic regression analysis, University-educated participants had increased odds of sufficient knowledge (OR: 1.774, 95%CI1.101-2.856) and positive attitude (OR: 4.246, 95%CI 1.545-11.669) about CC compared to the participant with secondary education. Moreover, participants with no family history of CC were less likely to have sufficient knowledge (OR: 0.554, 95%CI 0.102-2.745) and positive attitude (OR: 0.867, 95%CI 0.776 - 0.968) about CC compared to participants with positive family history. Also, sufficient knowledge was statistically associated with a positive attitude (OR: 1.754, 95%CI 1.112-2.849). Among all basic variables, participants' educational qualifications and positive family history of CC are significant socio- demographic predictors of CC knowledge and attitude. Specific educational interventions to enhance women's knowledge and attitude toward CC screening should be developed and implemented in the community without delay, particularly for less-educated women.&nbsp

Examining the risk perception of one of the most life-threatening cancers among women, such as cervical cancer, will guide the development of targeted advocacy and educational programs to reduce the burden of the disease. The current study investigated cervical cancer perceived risks and associated factors among Saudi women. A cross-sectional study was conducted through a social media-based survey, which conveniently targeted 1085 Saudi women in Najran city. The survey questionnaire consisted of four parts: basic sociodemographic data, cervical cancer knowledge quiz, attitude scale, and risk perception Scale. The present study confirmed that 57.4% of the study participants had high-risk perception regarding cervical cancer. Among the study participants, 42.6% had a low perception of the risk of cervical cancer, 57.3% had unsatisfactory knowledge, while 59.4% had a positive attitude (59.4%) towards cervical cancer prevention and its screening. The binary logistic regression proved that the positive significant factors associated with risk perception were higher education [AOR=3.105 (1.300 - 7.418), p=0.011], increasing age [AOR=1.191 (1.043-1.359), p=0.005], longer duration of marriage [AOR=3.123 (1.112 - 8.767), p=0.031], having family history of cancer/cervical cancer [AOR=4.498 (1.119 - 18.085), p=0.034], satisfactory knowledge [AOR=2.304 (1.289 - 4.116), p=0.005], and positive attitude [AOR=3.248 (2.532 - 4.166), p=0.000]. We conclude that more than half of the women in Najran city had high cervical cancer-related risk perception while more than two- fifths perceived low risk with unsatisfactory knowledge and a positive attitude. These results highlight the pressing need to develop cervical cancer health education programs to foster risk perception as a driving strategy for the prevention of cervical cancer in Saudi Arabian women.&nbsp