1. The effect of Cordia platythyrsa on various experimental models of pain and carrageenan induced inflammation
- Author
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Joseph T Mbafor, Lonwabo A. Dotwana, Benedicta N. Nkeh-Chungag, E. J. Ndebia, Opeopluwa Oyehan Oyedeji, and Jehu E Iputo
- Subjects
Aspirin ,biology ,business.industry ,Carrageenan induced inflammation ,Analgesic ,Inflammation ,Pharmacology ,Cordia platythyrsa ,biology.organism_classification ,Applied Microbiology and Biotechnology ,Genetics ,Morphine ,Celecoxib ,Medicine ,African traditional medicine ,medicine.symptom ,business ,Agronomy and Crop Science ,Molecular Biology ,Biotechnology ,medicine.drug - Abstract
Only one study has reported on the medicinal properties of Cordia platythyrsa (C. platythyrsa) though it is used in African traditional medicine for treatment of fever and pain. The current study aimed at investigating the analgesic and anti-inflammatory properties of C. platythyrsa using various animal models: writhing test, tail flick, thermal hyperalgesia, mechanically induced-pain, formalin-induced pain and carrageenan-induced inflammation tests. Like aspirin, the two doses of plant extracts used inhibited acetic acid-induced pain though these effects were weaker than the effects of morphine. Although, the plant extract significantly (p
- Published
- 2014
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