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The methanol extracts of Sphenocentrum Jollyanum organs were assessed for their anti-oxidant and anti-angiogenic activities using DPPH and CAM assays respectively. The results indicated the stem bark as the most active organ with an IC50 of 1.80 ± 0.25 and 1.00 ± 0.20 score (at 500 ìg/pellet) on DDPH and anti-angiogenesis assays respectively. Further fractionation of the stem bark revealed the chloroform fraction to have the highest IC50 1.54 ± 0.15 and the most important score on anti-angiogenesis assay with 1.3 ± 0.10 at 250 ìg/pellet when serially diluted between 250 and 36.2 ìg/pellet. Moreover, the effects were found to be dose-dependent. These results bring to the fore the need for further studies towards confirming the anti-oxidant and antiangiogenic potentials of the plant as well as identifying and characterizing the active principles for drug development

The methanol extracts of Sphenocentrum Jollyanum organs were assessed for their anti-oxidant and anti -angiogenic activities using DPPH and CAM assays respectively. The results indicated the stem bark as the most active organ with an IC50 of 1.80 ± 0.25 and 1.00 ± 0.20 score (at 500 μg/pellet) on DDPH and anti -angiogenesis assays respectively. Further fractionation of the stem bark revealed the chloroform fraction to have the highest IC50 1.54 ± 0.15 and the most important score on anti - angiogenesis assay with 1.3 ± 0.10 at 250 μg/pellet when serially diluted between 250 and 36.2 μg/pellet. Moreover, the effects were found to be dose-dependent. These results bring to the fore the need for further studies towards confirming the anti -oxidant and anti-angiogenic potentials of the plant as well as identifying and characterizing the active principles for drug development. African Journal of Biomedical Research Vol. 8(1) 2005: 4750

The methanol extracts of Sphenocentrum Jollyanum organs were assessed for their anti-oxidant and anti -angiogenic activities using DPPH and CAM assays respectively. The results indicated the stem bark as the most active organ with an IC 50 of 1.80 ± 0.25 and 1.00 ± 0.20 score (at 500 μg/pellet) on DDPH and anti -angiogenesis assays respectively. Further fractionation of the stem bark revealed the chloroform fraction to have the highest IC 50 1.54 ± 0.15 and the most important score on anti - angiogenesis assay with 1.3 ± 0.10 at 250 μg/pellet when serially diluted between 250 and 36.2 μg/pellet. Moreover, the effects were found to be dose-dependent. These results bring to the fore the need for further studies towards confirming the anti -oxidant and anti-angiogenic potentials of the plant as well as identifying and characterizing the active principles for drug development. African Journal of Biomedical Research Vol. 8(1) 2005: 4750