1. HLA-G and anti-HCV in patients on the waiting list for kidney transplantation
- Author
-
Carmela Iannone, Nicolò Rupealta, Linda Sommese, Vincenzo Grimaldi, Antonella Esposito, Rossella Paolillo, Antonio Sorriento, Francesco Cacciatore, Paride De Rosa, Chiara Sabia, Claudio Napoli, Michele Santangelo, Gianfranco Nicoletti, Gerardo Sarno, Sommese, Linda, Paolillo, Rossella, Cacciatore, Francesco, Grimaldi, Vincenzo, Sabia, Chiara, Esposito, Antonella, Sorriento, Antonio, Iannone, Carmela, Rupealta, Nicolò, Sarno, Gerardo, Santangelo, Michele, De Rosa, Paride, Nicoletti, Gianfranco, Napoli, Claudio, Sommese, L., Paolillo, R., Cacciatore, F., Grimaldi, V., Sabia, C., Esposito, A., Sorriento, A., Iannone, C., Rupealta, N., Sarno, G., Santangelo, M., De Rosa, P., Nicoletti, G., and Napoli, C.
- Subjects
Adult ,Male ,0301 basic medicine ,medicine.medical_specialty ,Waiting Lists ,Hepatitis C virus ,Hepacivirus ,HLA-G ,Human leukocyte antigen ,Antibodies, Viral ,medicine.disease_cause ,Major histocompatibility complex ,Gastroenterology ,03 medical and health sciences ,HLA-G Antigen ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,Age Factor ,Kidney transplantation ,Aged ,HLA-G Antigens ,Kidney ,Hepaciviru ,biology ,Tumor Necrosis Factor-alpha ,business.industry ,Medicine (all) ,Age Factors ,General Medicine ,Middle Aged ,biology.organism_classification ,medicine.disease ,Kidney Transplantation ,Interleukin-10 ,Transplantation ,030104 developmental biology ,medicine.anatomical_structure ,Solubility ,HCV ,biology.protein ,Female ,business ,Human ,030215 immunology - Abstract
Purpose Human leukocyte antigen (HLA)-G is a non-classic major histocompatibility complex HLA class I molecule. HLA-G may have tolerogenic properties which are linked to epigenetic-sensitive pathways. There is a correlation of sHLA-G levels and graft acceptance in transplantation studies. There are previous data on correlation of sHLA-G with graft rejection as well as with viral infections such as hepatitis C virus (HCV) in kidney transplanted patients. Here, we report the sHLA-G expression in patients on the waiting list for kidney transplantation, with and without anti-HCV compared to a control group. Methods Serum of 67 patients on the waiting list for kidney transplantation (n = 43 with anti-HCV and n = 24 without anti-HCV) was analyzed. Among these patients, n = 39 were on the waiting list for the first transplantation, while n = 28 were patients who returned in the list. The control group included n = 23 blood donors with anti-HCV (n = 13) and without anti-HCV (n = 10). Results The expression of sHLA-G was significantly lower in the control group (39.6 ± 34.1 U/ml) compared to both - patients on the waiting list for the first transplantation (62.5 ± 42.4 U/ml, p=0.031) and patients who returned in the list (76.7 ± 53.9 U/ml, p=0.006). No significant differences were observed in all anti-HCV positive groups. A positive linear correlation between sHLA-G and TNF-α, and patient age was observed. Conclusions Serum sHLA-G values were significantly increased in both - patients on the waiting list for the first transplantation and patients who returned in the list, as compared to control group. Our findings confirm the key tolerogenic role of sHLA-G levels as epigenetic-related marker for measuring the state of kidney allograft acceptance.
- Published
- 2018
- Full Text
- View/download PDF