1. Phenylacetate and phenylbutyrate as novel, nontoxic differentiation inducers.
- Author
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Samid D, Hudgins WR, Shack S, Liu L, Prasanna P, and Myers CE
- Subjects
- Adult, Antimetabolites, Antineoplastic therapeutic use, Brain Neoplasms drug therapy, Clinical Trials, Phase I as Topic, Humans, Male, Neoplasms drug therapy, Phenylbutyrates therapeutic use, Prostatic Neoplasms drug therapy, Transcription, Genetic drug effects, Tumor Cells, Cultured, Antimetabolites, Antineoplastic pharmacology, Cell Differentiation drug effects, Gene Expression Regulation, Neoplastic drug effects, Phenylacetates pharmacology, Phenylacetates therapeutic use, Phenylbutyrates pharmacology
- Abstract
Phenylacetate and analogs represent a new class of pleiotropic growth regulators that alter tumor cell biology by affecting gene expression at both the transcriptional and post transcriptional levels. Based on these findings, NaPA and NaPB entered clinical trials at the National Cancer Institute. Ongoing phase I studies with NaPA, involving adults with prostate and brain cancer, have confirmed that therapeutic levels can be achieved with no significant toxicities, and provide preliminary evidence for benefit to patients with advanced disease (Thibault et al., submitted).
- Published
- 1997
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