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Start Over Author "S. Strobel" Journal advances in experimental medicine and biology
9 results on '"S. Strobel"'

4. The role of antigen processing and suppressor T cells in immune responses to dietary proteins in mice

Author

A M, Mowat, A G, Lamont, S, Strobel, and S, Mackenzie

Subjects
Graft vs Host Reaction, Mice, Ovalbumin, Immune Tolerance, Administration, Oral, Animals, Antigen-Presenting Cells, Deoxyguanosine, Hypersensitivity, Delayed, Dietary Proteins, Mononuclear Phagocyte System, T-Lymphocytes, Regulatory, Food Hypersensitivity
Abstract

We have examined the role of Ts cels and APC in regulating the tolerance of systemic DTH in mice fed OVA. Oral tolerance to OVA was prevented by eliminating Ts with dGuo and by treating mice with anti-I-J antiserum. In addition, activating the reticuloendothelial system (RES) with oestradiol, muramyl dipeptide (MDP) or GvHR prevented the induction of tolerance. Further studies showed that prevention of oral tolerance correlated with the ability to enhance APC activity and that oestradiol also abrogated the induction of Ts after feeding OVA. Our results show that the tolerance of systemic DTH in mice fed OVA reflects complex interactions between APC and Ts and suggest that defects in these regulatory events may be responsible for clinical food sensitive enteropathy.

Published
1987

5. Immunomodulatory effects of breast milk oligosaccharides.

Author

Klein N, Schwertmann A, Peters M, Kunz C, and Strobel S

Subjects
Absorption, Adjuvants, Immunologic analysis, Cell Adhesion physiology, Endothelium, Vascular cytology, Female, Flow Cytometry, Humans, Immunity, Maternally-Acquired, In Vitro Techniques, Infant, Infant, Newborn, Ligands, Milk, Human chemistry, Milk, Human physiology, Oligosaccharides pharmacokinetics, Adjuvants, Immunologic physiology, Blood Platelets physiology, Endothelium, Vascular physiology, Milk, Human immunology, Neutrophils physiology, Oligosaccharides physiology
Abstract

Breast milk oligosaccharides are excreted in urine in amounts that suggest that they may exist in the circulation at levels compatible with a physiological function. Some oligosaccharides have structural similarity to cellular adhesion molecules and may influence adhesion of cells in breast fed infants. In this study, breast milk oligosaccharides were purified and incubated in assays of cell adhesion. They were found to inhibit neutrophil adhesion to stimulated vascular endothelial cells in a dose dependent fashion. In contrast they enhanced platelet-neutrophil complex formation. These results indicate that breast milk oligosaccharides may play a physiological role in modulating cellular adhesion in vivo.

Published
2000
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6. The absence of gut flora has no effect on the induction of oral tolerance to ovalbumin.

Author

Furrie E, Turner M, and Strobel S

Subjects
Administration, Oral, Animals, Blood Transfusion, Germ-Free Life, Hypersensitivity, Delayed, Immunity, Mucosal, Immunization, Passive, Immunoglobulin G biosynthesis, Intestinal Mucosa immunology, Intestinal Mucosa microbiology, Mice, Mice, Inbred BALB C, Ovalbumin administration & dosage, Antigens administration & dosage, Digestive System immunology, Digestive System microbiology, Immune Tolerance, Ovalbumin immunology
Published
1995

7. Evidence of a direct role for mucosal immune cells in the induction of oral tolerance.

Author

Furrie E, Turner M, and Strobel S

Subjects
Administration, Oral, Animals, Blood Transfusion, Hypersensitivity, Delayed, Immunization, Passive, Mice, Mice, Inbred BALB C, Mice, SCID, Ovalbumin administration & dosage, Ovalbumin blood, Ovalbumin immunology, Antigens administration & dosage, Immune Tolerance, Immunity, Mucosal
Published
1995

8. Raised IMP-dehydrogenase activity in the erythrocytes of a case of purine nucleoside phosphorylase (PNP) deficiency.

Author

Morgan G, Strobel S, Montero C, Duley JA, Davies PM, and Simmonds HA

Subjects
Child, Erythrocytes enzymology, Guanosine Triphosphate blood, Humans, Lymphocyte Activation, Male, Purine-Pyrimidine Metabolism, Inborn Errors immunology, T-Lymphocytes immunology, IMP Dehydrogenase blood, Purine-Nucleoside Phosphorylase deficiency, Purine-Pyrimidine Metabolism, Inborn Errors metabolism
Published
1991
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9. The role of antigen processing and suppressor T cells in immune responses to dietary proteins in mice.

Author

Mowat AM, Lamont AG, Strobel S, and Mackenzie S

Subjects
Administration, Oral, Animals, Deoxyguanosine pharmacology, Graft vs Host Reaction, Hypersensitivity, Delayed immunology, Immune Tolerance, Mice, Mononuclear Phagocyte System physiology, Ovalbumin administration & dosage, Ovalbumin immunology, Antigen-Presenting Cells immunology, Dietary Proteins immunology, Food Hypersensitivity immunology, T-Lymphocytes, Regulatory immunology
Abstract

We have examined the role of Ts cels and APC in regulating the tolerance of systemic DTH in mice fed OVA. Oral tolerance to OVA was prevented by eliminating Ts with dGuo and by treating mice with anti-I-J antiserum. In addition, activating the reticuloendothelial system (RES) with oestradiol, muramyl dipeptide (MDP) or GvHR prevented the induction of tolerance. Further studies showed that prevention of oral tolerance correlated with the ability to enhance APC activity and that oestradiol also abrogated the induction of Ts after feeding OVA. Our results show that the tolerance of systemic DTH in mice fed OVA reflects complex interactions between APC and Ts and suggest that defects in these regulatory events may be responsible for clinical food sensitive enteropathy.

Published
1987
Full Text
View/download PDF

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