1. Effect of high-intensity intermittent training under normobaric hypoxia on mitochondrial-related protein expression in rat gastrocnemius muscle.
- Author
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Shohei Dobashi, Toshinori Yoshiliara, and Naito Hisashi
- Abstract
Purpose: This study was to investigate the effect of high-intensity intermittent training (HITT) under normobaric hypoxic conditions on mitochondrial biogenesis and fission/fusion-related protein expressions in rat gastrocnemius muscle. Methods: Five-week-old Wistar male rats (n = 24) were randonily assigned to sedentary or training groups under normobaric normoxic (20.9% O
2 ) and hypoxic (14,5% O2 ) conditions. The training groups in both conditions were engaged in HHT on the treadmill for 9 weeks. From the 4111 week of the training period. the groups assigned to hypoxic conditions were exposed to normobaric hypoxia. Results: Hypoxic training enhanced citrate synthase activity as well as the protein levels of PGC- 1 a and the mitochondrial respiratory chain complex in the gastrocnemius muscle, when compared to the other 3 groups. Moreover, hypoxic training also elevated the level of expression of mitochondrial fusion-related protein (OPA 1 ) compared to the other groups. Discussion: 1-HIT under not-mobaric hypoxia improved the oxidative capacity of rat gastrocnemius muscles, possibly by increasing the expression of mitochondrial biogenesis and dynamics-related proteins. [ABSTRACT FROM AUTHOR]- Published
- 2022