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Start Over Author "Elford HL" Journal advances in enzyme regulation
3 results on '"Elford HL"'

1. Studies on the mechanisms of inhibition of L1210 cell growth by 3,4-dihydroxybenzohydroxamic acid and 3,4-dihydroxybenzamidoxime.

Author

Tihan T, Elford HL, and Cory JG

Subjects
Animals, Cell Line, Cytidine metabolism, Deoxyribonucleotides metabolism, Hydroxyurea pharmacology, Kinetics, Mice, Antineoplastic Agents pharmacology, Cell Division drug effects, Hydroxamic Acids pharmacology, Leukemia L1210 metabolism, Oximes pharmacology, Ribonucleotide Reductases antagonists & inhibitors
Abstract

Didox and Amidox inhibit L1210 cell growth in culture. At least one of the mechanisms in the mode(s) of action of the compounds is directed at the ribonucleotide reductase site. Partially purified preparations of ribonucleotide reductase activity are inhibited by Amidox and Didox. The formation of deoxycytidine nucleotides from [14C]cytidine in intact L1210 cells is also blocked. Didox and Amidox cause the decrease in the intracellular pools of the four dNTPs. Hydroxyurea-resistant L1210 cells are not cross-resistant to either Didox or Amidox. These data suggest that Didox and Amidox are not inhibiting ribonucleotide reductase through a mechanism similar to hydroxyurea.

Published
1991
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2. Regulation of ribonucleotide reductase in mammalian cells by chemotherapeutic agents.

Author

Elford HL, Van't Riet B, Wampler GL, Lin AL, and Elford RM

Subjects
Animals, Antineoplastic Agents therapeutic use, DNA biosynthesis, Deoxyribonucleotides metabolism, Female, HeLa Cells metabolism, Humans, Hydroxamic Acids pharmacology, Hydroxybenzoates pharmacology, Mice, Protein Biosynthesis, RNA biosynthesis, Antineoplastic Agents pharmacology, Leukemia L1210 drug therapy, Ribonucleoside Diphosphate Reductase antagonists & inhibitors, Ribonucleotide Reductases antagonists & inhibitors
Published
1980
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