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Start Over Author "W. J. Strittmatter" Journal advances in cyclic nucleotide research
1 results on '"W. J. Strittmatter"'

1. Regulation of the beta-adrenergic receptor by methylation of membrane phospholipids

Author

W J, Strittmatter, F, Hirata, and J, Axelrod

Subjects
Membrane Lipids, Reticulocytes, Membrane Fluidity, Cell Membrane, Erythrocyte Membrane, Lipid Bilayers, Receptors, Adrenergic, beta, Isoproterenol, Animals, Methyltransferases, Methylation, Phospholipids, Receptors, Adrenergic
Abstract

Stimulation of the beta-adrenergic receptor increases the enzymatic methylation of membrane phospholipids. Increased synthesis of phosphatidyl-N-monomethylethanolamine by methyltransferase I increases fluidity and enhances the ability of the beta-adrenergic receptor to couple with adenylate cyclase. The number of beta-adrenergic receptors can be regulated by the rate of synthesis and of degradation of phosphatidylcholine formed by transmethylation.

Published
1981

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