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The aim of the present work was to formulate flurbiprofen (FLB) loaded microspheres of hydroxypropylmethycellulose and ethylcellulose polymers to study the effect of different proportions of the polymer mixture on the release behavior of the drug.A series of microspheres were prepared using tween-80 as a surfactant. The prepared microspheres were evaluated for entrapment efficiency (%) and percentage recovery. Drug release was performed in USP phosphate buffers of pH 1.2 and 6.8. Drug release data were plotted in various kinetic models, including zero-order, first-order, Higuchi and Korsmeyer-Peppas models to investigate the optimum composition suitable for sustained drug delivery.A significant difference in drug release kinetics was observed by varying the composition of hydroxypropylmethycellulose/ethylcellulose. As the ratio of EC/HPMC was increased, the release rate of flurbiprofen decreased.This study demonstrated the potential of polymer combinations in the formulation of microspheres for water-insoluble drugs utilizing HPMC and EC as release retardant materials, using a simple solvent evaporation microencapsulation technique. It was observed that various physico-chemical properties of the microspheres varied according to the change in polymer concentrations used in the formulations.