1. Glial progenitors as targets for transformation in glioma.
- Author
-
Ilkhanizadeh S, Lau J, Huang M, Foster DJ, Wong R, Frantz A, Wang S, Weiss WA, and Persson AI
- Subjects
- Animals, Cell Differentiation genetics, Cell Lineage physiology, Glioma genetics, Glioma therapy, Humans, Molecular Targeted Therapy, Neural Stem Cells pathology, Neuroglia pathology, Cell Transformation, Neoplastic pathology, Glioma pathology, Neural Stem Cells physiology, Neuroglia physiology
- Abstract
Glioma is the most common primary malignant brain tumor and arises throughout the central nervous system. Recent focus on stem-like glioma cells has implicated neural stem cells (NSCs), a minor precursor population restricted to germinal zones, as a potential source of gliomas. In this review, we focus on the relationship between oligodendrocyte progenitor cells (OPCs), the largest population of cycling glial progenitors in the postnatal brain, and gliomagenesis. OPCs can give rise to gliomas, with signaling pathways associated with NSCs also playing key roles during OPC lineage development. Gliomas can also undergo a switch from progenitor- to stem-like phenotype after therapy, consistent with an OPC-origin even for stem-like gliomas. Future in-depth studies of OPC biology may shed light on the etiology of OPC-derived gliomas and reveal new therapeutic avenues., (© 2014 Elsevier Inc. All rights reserved.)
- Published
- 2014
- Full Text
- View/download PDF