1. The microRNA regulatory network in normal- and HTLV-1-transformed T cells.
- Author
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D'Agostino DM, Zanovello P, Watanabe T, and Ciminale V
- Subjects
- CD4-Positive T-Lymphocytes metabolism, CD4-Positive T-Lymphocytes virology, Cell Line, Cell Transformation, Neoplastic genetics, Cell Transformation, Viral, Gene Expression Regulation, Neoplastic, HTLV-I Infections genetics, HTLV-I Infections pathology, Human T-lymphotropic virus 1 metabolism, Humans, Leukemia-Lymphoma, Adult T-Cell genetics, Leukemia-Lymphoma, Adult T-Cell pathology, Leukemia-Lymphoma, Adult T-Cell virology, RNA, Messenger metabolism, Transcriptome, CD4-Positive T-Lymphocytes pathology, Human T-lymphotropic virus 1 genetics, Human T-lymphotropic virus 1 pathogenicity, MicroRNAs genetics, MicroRNAs metabolism
- Abstract
Recent efforts to understand the molecular networks governing normal T cell development and driving the neoplastic transformation of T cells have brought to light the involvement of microRNAs (miRNAs), a class of noncoding RNAs of approximately 22 nucleotides that regulate gene expression at the posttranscriptional level. In the present review, we compare the expression profiles of miRNAs in normal T cell development to that of transformed T cells using as a model adult T cell leukemia/lymphoma, an aggressive malignancy of mature CD4+ T cells that is caused by infection with human T cell leukemia virus type 1., (Copyright © 2012 Elsevier Inc. All rights reserved.)
- Published
- 2012
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