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Your search keyword '"Chen, Zhe-Sheng"' showing total 10 results
Start Over Author "Chen, Zhe-Sheng" Journal advanced science
10 results on '"Chen, Zhe-Sheng"'

1. Characterization of the Nucleus Pulposus Progenitor Cells via Spatial Transcriptomics

Author

Chen, Yu, primary, Zhang, Long, additional, Shi, Xueqing, additional, Han, Jie, additional, Chen, Jingyu, additional, Zhang, Xinya, additional, Xie, Danlin, additional, Li, Zan, additional, Niu, Xing, additional, Chen, Lijie, additional, Yang, Chaoyong, additional, Sun, Xiujie, additional, Zhou, Taifeng, additional, Su, Peiqiang, additional, Li, Na, additional, Greenblatt, Matthew B., additional, Ke, Rongqin, additional, Huang, Jianming, additional, Chen, Zhe‐Sheng, additional, and Xu, Ren, additional

Published
2024
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2. Behind the Indolent Facade: Uncovering the Molecular Features and Malignancy Potential in Lung Minimally Invasive Adenocarcinoma by Single‐Cell Transcriptomics

Author

Zhang, Xin, primary, Liang, Boxuan, additional, Huang, Yuji, additional, Meng, Hao, additional, Li, Zhiming, additional, Du, Jiaxin, additional, Zhou, Lang, additional, Zhong, Yizhou, additional, Wang, Bo, additional, Lin, Xi, additional, Yu, Guangchuang, additional, Chen, Xuewei, additional, Lu, Weixiang, additional, Chen, Zhe‐Sheng, additional, Yang, Xingfen, additional, and Huang, Zhenlie, additional

Published
2023
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4. MYH10 Combines with MYH9 to Recruit USP45 by Deubiquitinating Snail and Promotes Serous Ovarian Cancer Carcinogenesis, Progression, and Cisplatin Resistance

Author

Liu, Longyang, primary, Chen, Chunlin, additional, Liu, Ping, additional, Li, Jing, additional, Pang, Zhanjun, additional, Zhu, Jiayu, additional, Lin, Zhongqiu, additional, Zhou, Haixu, additional, Xie, Yingying, additional, Lan, Tiancai, additional, Chen, Zhe‐Sheng, additional, Zeng, Zhaoyang, additional, and Fang, Weiyi, additional

Published
2023
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5. The Single‐Cell Landscape of Intratumoral Heterogeneity and The Immunosuppressive Microenvironment in Liver and Brain Metastases of Breast Cancer

Author

Zou, Yutian, primary, Ye, Feng, additional, Kong, Yanan, additional, Hu, Xiaoqian, additional, Deng, Xinpei, additional, Xie, Jindong, additional, Song, Cailu, additional, Ou, Xueqi, additional, Wu, Song, additional, Wu, Linyu, additional, Xie, Yi, additional, Tian, Wenwen, additional, Tang, Yuhui, additional, Wong, Chau‐Wei, additional, Chen, Zhe‐Sheng, additional, Xie, Xinhua, additional, and Tang, Hailin, additional

Published
2022
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6. Stellettin B Sensitizes Glioblastoma to DNA‐Damaging Treatments by Suppressing PI3K‐Mediated Homologous Recombination Repair

Author

Peng, Xin, primary, Zhang, Shaolu, additional, Wang, Yingying, additional, Zhou, Zhicheng, additional, Yu, Zixiang, additional, Zhong, Zhenxing, additional, Zhang, Liang, additional, Chen, Zhe‐Sheng, additional, Claret, Francois X., additional, Elkabets, Moshe, additional, Wang, Feng, additional, Sun, Fan, additional, Wang, Ran, additional, Liang, Han, additional, Lin, Hou‐Wen, additional, and Kong, Dexin, additional

Published
2022
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9. The Single‐Cell Landscape of Intratumoral Heterogeneity and The Immunosuppressive Microenvironment in Liver and Brain Metastases of Breast Cancer.

Author

Zou, Yutian, Ye, Feng, Kong, Yanan, Hu, Xiaoqian, Deng, Xinpei, Xie, Jindong, Song, Cailu, Ou, Xueqi, Wu, Song, Wu, Linyu, Xie, Yi, Tian, Wenwen, Tang, Yuhui, Wong, Chau‐Wei, Chen, Zhe‐Sheng, Xie, Xinhua, and Tang, Hailin

Subjects
METASTATIC breast cancer, BRAIN metastasis, IMMUNE checkpoint proteins, REGULATORY T cells, FIBROBLASTS, LIVER cancer
Abstract

Distant metastasis remains the major cause of morbidity for breast cancer. Individuals with liver or brain metastasis have an extremely poor prognosis and low response rates to anti‐PD‐1/L1 immune checkpoint therapy compared to those with metastasis at other sites. Therefore, it is urgent to investigate the underlying mechanism of anti‐PD‐1/L1 resistance and develop more effective immunotherapy strategies for these patients. Using single‐cell RNA sequencing, a high‐resolution map of the entire tumor ecosystem based on 44 473 cells from breast cancer liver and brain metastases is depicted. Identified by canonical markers and confirmed by multiplex immunofluorescent staining, the metastatic ecosystem features remarkable reprogramming of immunosuppressive cells such as FOXP3+ regulatory T cells, LAMP3+ tolerogenic dendritic cells, CCL18+ M2‐like macrophages, RGS5+ cancer‐associated fibroblasts, and LGALS1+ microglial cells. In addition, PD‐1 and PD‐L1/2 are barely expressed in CD8+ T cells and cancer/immune/stromal cells, respectively. Interactions of the immune checkpoint molecules LAG3‐LGALS3 and TIGIT‐NECTIN2 between CD8+ T cells and cancer/immune/stromal cells are found to play dominant roles in the immune escape. In summary, this study dissects the intratumoral heterogeneity and immunosuppressive microenvironment in liver and brain metastases of breast cancer for the first time, providing insights into the most appropriate immunotherapy strategies for these patients. [ABSTRACT FROM AUTHOR]

Published
2023
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10. Stellettin B Sensitizes Glioblastoma to DNA‐Damaging Treatments by Suppressing PI3K‐Mediated Homologous Recombination Repair.

Author

Peng, Xin, Zhang, Shaolu, Wang, Yingying, Zhou, Zhicheng, Yu, Zixiang, Zhong, Zhenxing, Zhang, Liang, Chen, Zhe‐Sheng, Claret, Francois X., Elkabets, Moshe, Wang, Feng, Sun, Fan, Wang, Ran, Liang, Han, Lin, Hou‐Wen, and Kong, Dexin

Subjects
GLIOBLASTOMA multiforme, METHYLGUANINE, TRITERPENES, IONIZING radiation, BLOOD-brain barrier, CELL death, DNA damage, DNA repair, TEMOZOLOMIDE
Abstract

Glioblastoma (GBM) is the most aggressive type of cancer. Its current first‐line postsurgery regimens are radiotherapy and temozolomide (TMZ) chemotherapy, both of which are DNA damage‐inducing therapies but show very limited efficacy and a high risk of resistance. There is an urgent need to develop novel agents to sensitize GBM to DNA‐damaging treatments. Here it is found that the triterpene compound stellettin B (STELB) greatly enhances the sensitivity of GBM to ionizing radiation and TMZ in vitro and in vivo. Mechanistically, STELB inhibits the expression of homologous recombination repair (HR) factors BRCA1/2 and RAD51 by promoting the degradation of PI3Kα through the ubiquitin‐proteasome pathway; and the induced HR deficiency then leads to augmented DNA damage and cell death. It is further demonstrated that STELB has the potential to rapidly penetrate the blood‐brain barrier to exert anti‐GBM effects in the brain, based on zebrafish and nude mouse orthotopic xenograft tumor models. The study provides strong evidence that STELB represents a promising drug candidate to improve GBM therapy in combination with DNA‐damaging treatments. [ABSTRACT FROM AUTHOR]

Published
2023
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