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Aerogel‐based biomaterials are increasingly being considered for biomedical applications due to their unique properties such as high porosity, hierarchical porous network, and large specific pore surface area. Depending on the pore size of the aerogel, biological effects such as cell adhesion, fluid absorption, oxygen permeability, and metabolite exchange can be altered. Based on the diverse potential of aerogels in biomedical applications, this paper provides a comprehensive review of fabrication processes including sol‐gel, aging, drying, and self‐assembly along with the materials that can be used to form aerogels. In addition to the technology utilizing aerogel itself, it also provides insight into the applicability of aerogel based on additive manufacturing technology. To this end, how microfluidic‐based technologies and 3D printing can be combined with aerogel‐based materials for biomedical applications is discussed. Furthermore, previously reported examples of aerogels for regenerative medicine and biomedical applications are thoroughly reviewed. A wide range of applications with aerogels including wound healing, drug delivery, tissue engineering, and diagnostics are demonstrated. Finally, the prospects for aerogel‐based biomedical applications are presented. The understanding of the fabrication, modification, and applicability of aerogels through this study is expected to shed light on the biomedical utilization of aerogels. [ABSTRACT FROM AUTHOR]

Developing theranostic devices to detect bleeding and effectively control hemorrhage in the prehospital setting is an unmet medical need. Herein, an all‐in‐one theranostic platform is presented, which is constructed by sandwiching silk fibroin (SF) between two silver nanowire (AgNW) based conductive electrodes to non‐enzymatically diagnose local bleeding and stop the hemorrhage at the wound site. Taking advantage of the hemostatic property of natural SF, the device is composed of a shape‐memory SF sponge, facilitating blood clotting, with ≈82% reduction in hemostatic time in vitro as compared with untreated blood. Furthermore, this sandwiched platform serves as a capacitive sensor that can detect bleeding and differentiate between blood and other body fluids (i.e., serum and water) via capacitance change. In addition, the AgNW electrode endows anti‐infection efficiency against Escherichia coli and Staphylococcus aureus. Also, the device shows excellent biocompatibility and gradually biodegrades in vivo with no major local or systemic inflammatory responses. More importantly, the theranostic platform presents considerable hemostatic efficacy comparable with a commercial hemostat, Dengen, in rat liver bleeding models. The theranostic platform provides an unexplored strategy for the intelligent management of hemorrhage, with the potential to significantly improve patients' well‐being through the integration of diagnostic and therapeutic capabilities. [ABSTRACT FROM AUTHOR]

Aerogel-Based Biomaterials for Biomedical Applications: From Fabrication Methods to Disease-Targeting Applications (Adv. Sci. 23/2023) B Aerogel-Based Biomaterials b In light of the diverse capabilities of aerogels, article number 2204681 by Solmaz Karamikamkar, Han-Jun Kim, Ali Khademhosseini, and co-workers, presents a thorough examination of the fabrication processes, materials, and additive manufacturing techniques associated with aerogel technology. Additionally, it presents an extensive survey of the diverse biomedical applications that leverage the potential of aerogels, with a particular emphasis on addressing various diseases. [Extracted from the article]

An All-In-One Transient Theranostic Platform for Intelligent Management of Hemorrhage (Adv. Sci. 24/2023) Such a platform provides an unexplored strategy for intelligent hemorrhage management and post-operative infection control. B Theranostic Devices b In article number 2301406 by Reihaneh Haghniaz, Ali Khademhosseini, Yangzhi Zhu, and co-workers, an all-in-one theranostic platform is presented that is constructed by sandwiching a highly porous silk sponge between two silver nanowire-based conductive electrodes to non-enzymatically diagnose local bleeding and stop the hemorrhage at the wound site. [Extracted from the article]