1. Synthesize of Carboxymethyl Chitosan-Graft-Polycaprolactone (CMCS-g-PCL) and the Preparation of Micelles
- Author
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Heng Xu, Meng Ru Zhang, and Mei Dong Lang
- Subjects
Thermogravimetric analysis ,Materials science ,technology, industry, and agriculture ,General Engineering ,Micelle ,chemistry.chemical_compound ,Graft polymer ,chemistry ,Polymerization ,Chemical engineering ,Polycaprolactone ,Polymer chemistry ,Copolymer ,Particle size ,Drug carrier - Abstract
In this study, we synthesized carboxymethyl chitosan-graft-poly(ε-caprolactone) (CMCS-g-PCL) by grafting ε-CL onto the hydroxyl groups of CMCS via ring-opening polymerization. The graft copolymers were characterized by 1H NMR spectroscopy and thermogravimetric analysis (TGA). Then use the graft copolymer to produce the micelle by solvent-evaporation method. The DLS and TEM were utilized to evaluate the particle size and morphology and showed that the micelles were in a well-defined spherical shape with a uniform size distribution. The results indicated that the size of range is below 200 nm and could be used as drug carrier and have better active cellular uptake.
- Published
- 2015
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