1. Confinement of Dyes inside Boron Nitride Nanotubes: Photostable and Shifted Fluorescence down to the Near Infrared
- Author
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Richard Martel, Gaëlle Recher, Etienne Gaufrès, Frédéric Fossard, Patrick Desjardins, Rafaella O. do Nascimento, Léonard Schué, Annick Loiseau, Emmanuel Flahaut, Charlotte Allard, Centre National de la Recherche Scientifique - CNRS (FRANCE), Ecole Polytechnique de Montréal (CANADA), Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE), Institut d'optique Graduate School - IOGS (FRANCE), Office National d'Etudes et Recherches Aérospatiales - ONERA (FRANCE), Université Paris-Saclay (FRANCE), Université de Montréal - UdeM (CANADA), Université Toulouse III - Paul Sabatier - UT3 (FRANCE), Université de Bordeaux (FRANCE), Laboratoire d'étude des microstructures - LEM (Chatillon, France), Laboratoire Photonique, Numérique, Nanosciences - LP2N (Talence, France), École Polytechnique de Montréal (EPM), Université de Montréal (UdeM), DMAS, ONERA, Université Paris Saclay [Châtillon], ONERA-Université Paris-Saclay, LEM, UMR 104, CNRS-ONERA, Université Paris-Saclay (Laboratoire d'étude des microstructures), ONERA-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Laboratoire Photonique, Numérique et Nanosciences (LP2N), Université de Bordeaux (UB)-Institut d'Optique Graduate School (IOGS)-Centre National de la Recherche Scientifique (CNRS), Centre interuniversitaire de recherche et d'ingenierie des matériaux (CIRIMAT), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), and Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)
- Subjects
Boron Compounds ,Materials science ,Passivation ,Infrared Rays ,Matériaux ,Molecular aggregation ,02 engineering and technology ,010402 general chemistry ,Photochemistry ,01 natural sciences ,Photostable fluorescence ,Fluorescence ,[SPI.MAT]Engineering Sciences [physics]/Materials ,Diffusion ,chemistry.chemical_compound ,Drug Stability ,Time windows ,Cell Line, Tumor ,Molecule ,Humans ,General Materials Science ,Bio‐imaging ,Coloring Agents ,Nanotubes ,Mechanical Engineering ,Near-infrared spectroscopy ,Optical Imaging ,Nanotube heterostructure ,021001 nanoscience & nanotechnology ,Boron nitride nanotube ,3. Good health ,0104 chemical sciences ,chemistry ,Mechanics of Materials ,Boron nitride ,Organic dye ,0210 nano-technology ,NIR‐II fluorescence - Abstract
International audience; Fluorescence is ubiquitous in life science and used in many fields of research ranging from ecology to medicine. Among the most common fluorogenic compounds, dyes are being exploited in bioimaging for their outstanding optical properties from UV down to the near IR (NIR). However, dye molecules are often toxic to living organisms and photodegradable, which limits the time window for in vivo experiments. Here, it is demonstrated that organic dye molecules are passivated and photostable when they are encapsulated inside a boron nitride nanotube (dyes@BNNT). The results show that the BNNTs drive an aggregation of the encapsulated dyes, which induces a redshifted fluorescence from visible to NIR‐II. The fluorescence remains strong and stable, exempt of bleaching and blinking, over a time scale longer than that of free dyes by more than 104. This passivation also reduces the toxicity of the dyes and induces exceptional chemical robustness, even in harsh conditions. These properties are highlighted in bioimaging where the dyes@BNNT nanohybrids are used as fluorescent nanoprobes for in vivo monitoring of Daphnia Pulex microorganisms and for diffusion tracking on human hepatoblastoma cells with two‐photon imaging.
- Published
- 2020
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