1. An Optical Nanoruler Based on a Conjugated Polymer−Silver Nanoprism Pair for Label-Free Protein Detection
- Author
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Shengliang Li, Lidong Li, Fengting Lv, Shu Wang, Xiaoyu Wang, Pengbo Zhang, and Libing Liu
- Subjects
Materials science ,Nanostructure ,Polymers ,Nanotechnology ,Conjugated system ,Photochemistry ,Fluorescence ,Protein detection ,Electrolytes ,Nanoruler ,Microscopy, Electron, Transmission ,Humans ,General Materials Science ,Antigens ,Label free ,chemistry.chemical_classification ,Spectrum Analysis ,Mechanical Engineering ,Optical Devices ,Proteins ,Silver Compounds ,Equipment Design ,Polymer ,Conjugated Polyelectrolytes ,Nanostructures ,chemistry ,Mechanics of Materials ,MCF-7 Cells ,Microscopy, Electron, Scanning - Abstract
An optical nanoruler system based on a conjugated polyelectrolyte-silver nanoprism pair is developed for label-free protein detection by taking advantage of the metal-enhanced fluorescence effect of silver nanostructures. Antibody-antigen interactions induce a change in the metal-fluorophore distance, followed by the response of a fluorescent signal of the conjugated polyelectrolyte. The system is used to detect target antigens sensitively and selectively.
- Published
- 2015
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