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Biomimetic mineralization of live organisms shows extraordinary promise in biotechnology. However, their therapeutic applications have been insufficiently explored. Herein, it is demonstrated that metal-organic framework (MOF)-engineered bacteria are powerful carriers for tumor-targeted therapeutic delivery. Specifically, Escherichia coli (MG1655) is coated with a zeolitic imidazolate framework-8 layer coloaded with a photosensitizer and chemical drug through a one-step in situ method. The as-prepared bacteria@MOF hybrid preserves its viability and tumor selectivity. It exhibits high therapeutic efficacy both in vitro and in vivo in a combined chemo-photodynamic manner. To the best of knowledge, this is the first report of engineered bacteria@MOFs for in vivo tumor treatment. This study opens a new horizon for the bioapplications of biomineralized organisms and may provide novel strategies against tumors.