1. Covalent Organic Framework-Based Nanomotor for Multimodal Cancer Photo-Theranostics.
- Author
-
Feng J, Yang SP, Shao YQ, Sun YY, He ZL, Wang Y, Zhai YN, and Dong YB
- Subjects
- Humans, Polymers, Pyrroles pharmacology, Precision Medicine, Cell Line, Tumor, Metal-Organic Frameworks, Neoplasms therapy
- Abstract
Developing efficient integrated diagnosis and treatment agents based on fuel-free self-movement nanomotors remains challenging in antitumor therapy. In this study, a covalent organic framework (COF)-based biomimetic nanomotor composed of polypyrrole (PPy) core, porphyrin-COF shell, and HCT116 cancer cell membrane coating is reported. Under near-infrared (NIR) light irradiation, the obtained mPPy@COF-Por can overcome Brownian motion and achieves directional motion through self-thermophoretic force generated from the PPy core. The HCT116 cancer cell membrane coating enables the nanomotor to selectively recognize the source cell lines and reduces the bio-adhesion of mPPy@COF-Por in a biological medium, endowing with this NIR light-powered nanomotor good mobility. More importantly, such multifunctional integration allows the COF-based nanomotor to be a powerful nanoagent for cancer treatment, and the high infrared thermal imaging/photoacoustic imaging/fluorescence trimodal imaging-guided combined photothermal/photodynamic therapeutic effect on HCT116 tumor cell is successfully achieved. The results offer considerable promise for the development of COF nanomotors with integrated imaging/therapy modalities in biomedical applications., (© 2023 Wiley-VCH GmbH.)
- Published
- 2023
- Full Text
- View/download PDF