1. Relationship between the prehospital quick Sequential Organ Failure Assessment and prognosis in patients with sepsis or suspected sepsis: a population-based ORION registry
- Author
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Yutaka Umemura, Yasuaki Mizushima, Tetsuhisa Kitamura, Yusuke Katayama, Hiroshi Ogura, Tomoya Hirose, and Takeshi Shimazu
- Subjects
medicine.medical_specialty ,education.field_of_study ,Receiver operating characteristic ,business.industry ,RC86-88.9 ,Population ,General Engineering ,Glasgow Coma Scale ,Medical emergencies. Critical care. Intensive care. First aid ,Odds ratio ,Original Articles ,medicine.disease ,survival ,Confidence interval ,infection ,Sepsis ,Emergency medical service ,Blood pressure ,qSOFA ,Interquartile range ,Emergency medicine ,Medicine ,Original Article ,business ,education - Abstract
Aim The quick Sequential Organ Failure Assessment (qSOFA) was proposed for use as a simple screening tool for sepsis. In this study, we evaluated the relationship between the prehospital use of qSOFA and prognosis in patients with sepsis or suspected sepsis using the population‐based Osaka Emergency Information Research Intelligent Operation Network (ORION) registry, which compiles prehospital ambulance data and in‐hospital information. Methods The study enrolled 437,974 patients in the ORION registry from January 1 to December 31, 2016. We selected hospitalized patients with sepsis or suspected sepsis using the appropriate codes from the International Classification of Diseases revision 10. We excluded patients with: (i) missing data (outcome, Japan Coma Scale, respiratory rate, and blood pressure); (ii) respiratory rate ≥60/min; and (iii) blood pressure ≥250 mmHg. These measures were evaluated by ambulance personnel when they first contacted the patient in the prehospital setting. The primary end‐point was discharge to death. Results In total, 12,646 patients (median age, 78 [interquartile range, 65–85] years; male, n = 6,760 [53.5%]) were eligible for our analysis. In a multivariable logistic regression analysis adjusted for confounding factors, the proportion of patients discharged to death was significantly higher for those evaluated as qSOFA positive (≥2 points) than qSOFA negative (≤1 point) (265/2,250 [11.78%] vs. 415/10,396 [3.99%]; adjusted odds ratio 2.91; 95% confidence interval, 2.47–3.43; P, In 2016, the quick Sequential Organ Failure Assessment (qSOFA) was proposed for use as a simple index for sepsis. From an analysis of the population‐based ORION registry in Osaka, Japan, our study revealed that the proportion of patients discharged to death was significantly higher in those with sepsis or suspected sepsis evaluated as qSOFA positive versus negative by emergency medical service personnel in the prehospital setting.
- Published
- 2021